Probabilistic approach for the risk assessment of nanomaterials: A case study for graphene nanoplatelets

International Journal of Hygiene and Environmental Health
Andrea SpinazzèDomenico M Cavallo

Abstract

An experimental probabilistic approach for health risk assessment was applied for graphene nanoplatelets (GNPs). The hazard assessment indicated a low level of toxicity for the GNPs. The benchmark dose method, based on sub-chronic and chronic inhalation exposure studies, was used to quantify a guidance value (BMCh) for occupational inhalation exposure to GNPs, expressed as a lognormal distribution with a geometric mean ± geometric standard deviation of 0.212 ± 7.79 mg/m3 and 9.37 × 104 ± 7.6 particle/cm3. Exposure scenarios (ES) were defined based on the scientific literature for large-scale production (ES1) and manufacturing (ES2) of GNPs; a third ES, concerning in-lab handling of GNPs (ES3) was based on results of experiments performed for this study. A probability distribution function was then assumed for each ES. The risk magnitude was calculated using a risk characterization ratio (RCR), defined as the ratio of the exposure distributions and the BMCh distribution. All three ES resulted in RCR distributions ≥1 (i.e. risk present); however, none of the ES had a statistically significant level of risk at a 95% confidence interval. A sensitivity analysis indicated that ∼75% of the variation in the RCR distributions was due to...Continue Reading

Citations

Jun 18, 2020·Journal of Exposure Science & Environmental Epidemiology·Karin LovénUNKNOWN NanoLund
Feb 11, 2021·Nanomaterials·Andrea SpinazzèDomenico M Cavallo
Mar 2, 2021·The Science of the Total Environment·Tanushree Parsai, Arun Kumar
Dec 2, 2020·Ecotoxicology and Environmental Safety·Alicia A TaylorMerel J C van der Ploeg

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