Probabilistic classification learning in Tourette syndrome

Neuropsychologia
S KériJúlia Gádoros

Abstract

Tourette syndrome (TS) is characterised by stereotyped involuntary movements, called tics. Some evidence suggests that structural and functional abnormalities of the basal ganglia may explain these motor symptoms. In this study, the probabilistic classification learning (PCL) test was used to evaluate basal ganglia functions in 10 children with less severe tics (Yale Global Tic Severity Scale (YGTSS) scores<30) and in 10 children with more severe symptoms (YGTSS score>30). In the PCL task, participants are asked to decide whether different combinations of four geometric forms (cues) predict rainy or sunny weather. Each cue is probabilistically related to a weather outcome, and feedback is provided after each decision. After completion of the probabilistic stimulus-response learning procedure, subjects received a transfer test to assess explicit knowledge about the cues. The children with TS exhibited impaired learning in the PCL task in comparison with the 20 healthy control subjects. This impairment was more pronounced in the TS patients with severe symptoms, and there was a significant negative relationship between the final classification performance and the YGTSS scores. The patients showed normal learning in the transfer t...Continue Reading

References

Jun 1, 1991·Psychiatry Research·R A Bornstein
Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Apr 1, 1967·Journal of Comparative and Physiological Psychology·I DivacM K Szwarcbart
Aug 1, 1995·Journal of Autism and Developmental Disorders·V P Prasher, S Day
Dec 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A R BraunT N Chase
Jan 1, 1996·Journal of Child Psychology and Psychiatry, and Allied Disciplines·B F Pennington, S Ozonoff
Sep 6, 1996·Science·B J KnowltonL R Squire
Aug 1, 1997·Neurology·J MoriartyM M Robertson
Nov 1, 1995·Journal of the International Neuropsychological Society : JINS·E L HarrisM B Denckla
Feb 14, 1998·Neuropsychology·Robert T SchultzDavid Pauls
Dec 9, 1998·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S OzonoffF Filloux
Jul 27, 1999·Journal of Clinical and Experimental Neuropsychology·W J LombardiD W Hommer
Oct 20, 1999·Neuropsychology·R A PoldrackJ D Gabrieli
Jun 1, 1994·Psychiatry Research·B S PetersonD J Cohen
Aug 2, 2000·Archives of General Psychiatry·E SternR J Dolan
Oct 1, 1998·Trends in Cognitive Sciences·A D LawrenceT W Robbins

❮ Previous
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Citations

Sep 5, 2007·European Child & Adolescent Psychiatry·Kerstin J PlessenBradley S Peterson
Sep 23, 2003·Brain Research. Brain Research Reviews·Szabolcs Kéri
Jan 1, 2013·The Journal of General Psychology·Ferenc Kemény, Ágnes Lukács
Mar 6, 2010·The Quarterly Journal of Experimental Psychology : QJEP·Jamie BrownKate Plaisted Grant
Dec 13, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·James G PerrettaRichard J Beninger
Mar 26, 2013·Acta Psychologica·Ferenc Kemény, Agnes Lukács
Oct 19, 2010·Pediatrics and Neonatology·Jung-Chieh DuJames F Leckman
Apr 7, 2010·Neuropsychologia·C Mayor-DuboisE Roulet-Perez
Sep 15, 2007·Neuroscience and Biobehavioral Reviews·Szabolcs Kéri
Aug 2, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·James E SwainJames F Leckman
May 23, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·James F LeckmanAribert Rothenberger
May 3, 2016·Journal of Obsessive-compulsive and Related Disorders·Benjamin KelmendiChristopher Pittenger
Jul 15, 2015·Behavior Therapy·Ulrike ZetscheCornelia Exner
Apr 23, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Elizabeth ShephardMadeleine J Groom
Apr 23, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Elizabeth ShephardMadeleine J Groom
Aug 2, 2016·Brain and Language·Cristina D DyeMichael T Ullman
Jul 6, 2011·Brain : a Journal of Neurology·Stefano PalminteriMathias Pessiglione
Sep 15, 2006·Journal of Child Neurology·James F LeckmanRobert A King
Dec 19, 2007·Developmental Psychobiology·Emily R SternBradley S Peterson
Sep 14, 2018·F1000Research·Andreas HartmannKevin J Black
Mar 16, 2021·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Eszter Tóth-FáberÁdám Takács
Jun 19, 2021·PloS One·Canan Beate SchüllerJens Kuhn

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