Probabilistic cost-effectiveness analysis of controlled ovarian stimulation with recombinant FSH plus recombinant LH vs. human menopausal gonadotropin for women undergoing IVF

Reproductive Biology and Endocrinology : RB&E
Francesco Saverio MenniniChiara Benedetto

Abstract

The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled Ovarian Stimulation (COS) with recombinant FSH (rFSH) plus recombinant LH (rLH) in comparison with highly purified human menopausal gonadotropin (HP-hMG) in the woman undergoing in vitro fertilization (IVF) in Italy. A probabilistic decision tree was developed to simulate patients undergoing IVF, either using r-FSH + r-LH or HP-hMG to obtain COS. The model considers the National Health System (NHS) perspective and a time horizon equal to two years. Simulations were reported considering the number of retrieved oocytes (5-9, 10-15 and > 15) and transition probabilities were estimated through specific analyses carried out on the population of 848 women enrolled in the real-life. The model estimated that patients undertaking therapeutic protocol with r-FSH + r-LH increase the general success rate (+ 6.6% for pregnancy). The incremental cost-effectiveness ratio (ICER) per quality-adjusted life year (QALY) of r-FSH + r-LH was bel...Continue Reading

References

Dec 23, 2003·Health and Quality of Life Outcomes·Luis Prieto, José A Sacristán
Sep 25, 2004·Human Reproduction Update·Bruno Lunenfeld
Jan 17, 2012·Fertility and Sterility·Paul DevroeyUNKNOWN Menopur in GnRH Antagonist Cycles with Single Embryo Transfer Trial Group
Sep 24, 2015·Heart·Olivier J WoutersNilesh J Samani
Jan 20, 2017·Endocrine Journal·Koji Shiraishi, Hideyasu Matsuyama

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