Probabilistic dose distribution from interfractional motion in carbon ion radiation therapy for prostate cancer shows rectum sparing with moderate target coverage degradation

PloS One
Daniel BridgesTatsuaki Kanai

Abstract

This observational study investigates the influence of interfractional motion on clinical target volume (CTV) coverage, planning target volume (PTV) margins, and rectum tissue sparing in carbon ion radiation therapy (CIRT). It reports dose coverage to target structures and organs at risk in the presence of interfractional motion, investigates rectal tissue sparing, and provides recommendations for lowering the rate of toxicity. We also propose probabilistic DVH based on cone-beam computed tomography (CBCT) table shifts from photon therapy for consideration in bone-matching CIRT treatment planning to represent probable dose to our CIRT patient population. At Gunma University Hospital intensity-modulated x-ray therapy (IMXT, aka IMRT) prostate cancer patients are positioned on a table which is shifted twice based on CBCT to align bones and then align prostate tissue to isocenter. These shifts thereby contain interfractional motion. A total of 1306 such table shifts from 85 patients were collected. Normal probability distributions were fit to the difference between bone-matching and prostate-matching CBCT-to-planning CT table shifts (i.e. interfractional motion). Between 2011 and 2016 CIRT prostate patients were treated with three...Continue Reading

References

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Citations

Jun 21, 2020·Radiation and Environmental Biophysics·Metin Usta, Güral Aydın
Nov 5, 2020·International Journal of Molecular Sciences·Sharda KumariAroumougame Asaithamby
Aug 3, 2021·Journal of Applied Clinical Medical Physics·Toshiro TsubouchiTatsuaki Kanai

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Methods Mentioned

BETA
carbon beam
irradiate

Software Mentioned

RTiS
Elekta
MIM
Plan
CIRT
InfoCom
IMXT
MATLAB
Elekta XVI
RT

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