Probabilistic expert systems for forensic inference from DNA markers in horses: applications to confirm genealogies with lack of genetic data

The Journal of Heredity
Marina DoboszPaolo De Iuliis

Abstract

Microsatellites have been used for parentage testing and individual identification in forensic science because they are highly polymorphic and show abundant sequences dispersed throughout most eukaryotic nuclear genomes. At present, genetic testing based on DNA technology is used for most domesticated animals, including horses, to confirm identity, to determine parentage, and to validate registration certificates. But if genetic data of one of the putative parents are missing, verifying a genealogy could be questionable. The aim of this paper is to illustrate a new approach to analyze complex cases of disputed relationship with microsatellites markers. These cases were solved by analyzing the genotypes of the offspring and other horses' genotypes in the pedigrees of the putative dam/sire with probabilistic expert systems (PESs). PES was especially efficient in supplying reliable, error-free Bayesian probabilities in complex cases with missing pedigree data. One of these systems was developed for forensic purposes (FINEX program) and is particularly valuable in human analyses. We applied this program to parentage analysis in horses, and we will illustrate how different cases have been successfully worked out.

References

Jan 1, 1992·Animal Genetics·H EllegrenL Andersson
Jul 1, 1995·Carcinogenesis·C P SarisL den Engelse
Aug 1, 1997·Animal Genetics·A T BowlingE Wictum
Aug 12, 1999·Animal Genetics·T L LearK Bell
Jan 5, 2002·The Journal of Veterinary Medical Science·T TozakiM Tomita
Jul 10, 2003·Forensic Science International : Synergy·Robert G Cowell
Apr 19, 2005·International Journal of Legal Medicine·Bruce BudowleTom Broad
Jan 26, 2006·Journal of Veterinary Science·Sun-young Lee, Gil-jae Cho
Dec 17, 2008·Forensic Science International. Genetics·Amanda B Hepler, Bruce S Weir
Dec 17, 2008·Forensic Science International. Genetics·David W GjertsonNiels Morling

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Citations

Jun 8, 2011·Journal of Forensic Sciences·Lindsay AllgeierHeather Miller Coyle

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