Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease

Journal of Magnetic Resonance Imaging : JMRI
Camilo JaimesLilla Zöllei

Abstract

Given the central role of the thalamus in motor, sensory, and cognitive development, methods to study emerging thalamocortical connectivity in early infancy are of great interest. To determine the feasibility of performing probabilistic tractography-based thalamic parcellation (PTbTP) in typically developing (TD) neonates and to compare the results with a pilot sample of neonates with congenital heart disease (CHD). Institutional Review Board (IRB)-approved cross-sectional study. We prospectively recruited 20 TD neonates and five CHD neonates (imaged preoperatively). MRI was performed at 3.0T including diffusion-weighted imaging (DWI) and 3D magnetization prepared rapid gradient-echo (MPRAGE). A radiologist and trained research assistants segmented the thalamus and seven cortical targets for each hemisphere. Using the thalami as seeds and the cortical labels as targets, FSL library tools were used to generate probabilistic tracts. A Hierarchical Dirichlet Process algorithm was then used for clustering analysis. A radiologist qualitatively assessed the results of clustering. Quantitative analyses were also performed. We summarized the demographic data and results of clustering with descriptive statistics. Linear regressions cova...Continue Reading

References

Nov 22, 1988·The Journal of Comparative Neurology·J R NaegeleG E Schneider
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·David C BellingerJane W Newburger
Nov 17, 2005·Nature Reviews. Neuroscience·Giorgio M Innocenti, David J Price
Jan 19, 2006·Circulation·Jane W Newburger, David C Bellinger
Nov 9, 2007·The New England Journal of Medicine·Steven P MillerDaniel B Vigneron
Dec 26, 2007·Magnetic Resonance Imaging·Mohamed L Seghier
Feb 5, 2008·NeuroImage·André J W van der KouweBruce Fischl
Jun 20, 2008·Cerebral Cortex·J DuboisG Dehaene-Lambertz
Aug 9, 2008·AJNR. American Journal of Neuroradiology·J DudinkS J Counsell
Dec 9, 2008·NeuroImage·Mark W WoolrichStephen M Smith
Jan 16, 2010·AJNR. American Journal of Neuroradiology·J I BermanO A Glenn
Aug 7, 2010·Medical Image Analysis·Yangming OuChristos Davatzikos
Nov 3, 2010·Neuropsychology Review·Joan Stiles, Terry L Jernigan
Jul 21, 2011·Cerebral Cortex·Gareth BallSerena J Counsell
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Dylan TisdallAndré J W van der Kouwe
Jan 18, 2012·NeuroImage·Bruce Fischl
Jan 31, 2012·Journal of Clinical Ultrasound : JCU·Alexandros SotiriadisGeorge Makrydimas
Sep 11, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gareth BallSerena J Counsell
Mar 19, 2013·NeuroImage·Nagulan RatnarajahAnqi Qiu
May 9, 2014·Cerebral Cortex·Jae W SongEmi Takahashi
Jan 18, 2015·Cerebral Cortex·Gareth BallSerena J Counsell
Jan 23, 2015·Pediatric Cardiology·Lisa B PaquetteAshok Panigrahy
Mar 6, 2015·Frontiers in Human Neuroscience·Katyucia de Macedo RodriguesLilla Zöllei
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hilary ToulminA David Edwards
Sep 21, 2016·Annals of Clinical and Translational Neurology·Ala BircaCecil D Hahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.