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Probabilities of Fitness Consequences for Point Mutations Across the Human Genome

bioRxiv

Jul 2, 2014

Brad GulkoAdam Siepel

Abstract

We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fit-Cons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster geno...read more

Mentioned in this Paper

Computed (Procedure)
Biochemical Turnover
Nucleotides
Genetic Polymorphism
Gene Function
Study
Cell Type
Pan troglodytes
Gene Polymorphism
Human Cell Line
31
35
Paper Details
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Probabilities of Fitness Consequences for Point Mutations Across the Human Genome

bioRxiv

Jul 2, 2014

Brad GulkoAdam Siepel

PMID: 990006825

DOI: 10.1101/006825

Abstract

We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fit-Cons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster geno...read more

Mentioned in this Paper

Computed (Procedure)
Biochemical Turnover
Nucleotides
Genetic Polymorphism
Gene Function
Study
Cell Type
Pan troglodytes
Gene Polymorphism
Human Cell Line
31
35
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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