Probability modeling of the number of positive cores in a prostate cancer biopsy session, with applications

Statistics in Medicine
Robert Serfling, Gerald Ogola

Abstract

Among men, prostate cancer (CaP) is the most common newly diagnosed cancer and the second leading cause of death from cancer. A major issue of very large scale is avoiding both over-treatment and under-treatment of CaP cases. The central challenge is deciding clinical significance or insignificance when the CaP biopsy results are positive but only marginally so. A related concern is deciding how to increase the number of biopsy cores for larger prostates. As a foundation for improved choice of number of cores and improved interpretation of biopsy results, we develop a probability model for the number of positive cores found in a biopsy, given the total number of cores, the volumes of the tumor nodules, and - very importantly - the prostate volume. Also, three applications are carried out: guidelines for the number of cores as a function of prostate volume, decision rules for insignificant versus significant CaP using number of positive cores, and, using prior distributions on total tumor size, Bayesian posterior probabilities for insignificant CaP and posterior median CaP. The model-based results have generality of application, take prostate volume into account, and provide attractive tradeoffs of specificity versus sensitivity...Continue Reading

References

Jan 1, 1997·Urology·P I KarakiewiczM M Elhilali
Oct 7, 1997·CA: a Cancer Journal for Clinicians·D G Bostwick
Oct 23, 1998·The Journal of Urology·J L LetranM K Brawer
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Aug 30, 2005·European Urology·L M Boccon-GibodL A Boccon-Gibod
Jan 13, 2006·The Journal of Urology·J Stephen JonesCristina Magi-Galluzzi
May 19, 2007·The Journal of Urology·Adam S Kibel
Jun 19, 2007·The Journal of Urology·Amit R Patel, J Stephen Jones
Sep 13, 2007·Journal of the National Cancer Institute·Gerald L AndrioleRobert L Grubb
Mar 20, 2009·The New England Journal of Medicine·Thomas H LeeMary F McNaughton-Collins
Mar 20, 2009·The New England Journal of Medicine·Michael J Barry
Jul 1, 2009·CA: a Cancer Journal for Clinicians·Otis W BrawleyIan M Thompson
Aug 12, 2009·Lancet·David E NealFreddie C Hamdy
Sep 20, 2011·Urologic Oncology·Dan LeiboviciAmnon Zisman
Jun 29, 2012·Urologia Internationalis·Antonio CicioneRocco Damiano
Jul 18, 2012·Annals of Internal Medicine·Virginia A Moyer, UNKNOWN U.S. Preventive Services Task Force
Jun 27, 2013·JAMA : the Journal of the American Medical Association·Bruce L JacobsBrent K Hollenbeck

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Citations

Jul 2, 2019·Applied Health Economics and Health Policy·Haitham W TuffahaPaul A Scuffham

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