Probable levetiracetam-associated depression in the elderly: two case reports

The American Journal of Geriatric Pharmacotherapy
Joseph P Vande GriendJacquelyn L Bainbridge

Abstract

Compared with traditional antiepileptic drugs, levetiracetam has a unique mechanism of action and unique properties, including predominant renal excretion and lack of drug-drug interactions. In the elderly, depression associated with levetiracetam has not been reported. A 73-year-old black man (height, 172.7 cm; weight, 92.7 kg; body mass index [BMI], 31 kg/m(2)) with stage 4 kidney disease was taking levetiracetam 500 mg BID for partial complex seizures. After 5 months of taking medication, new-onset depression, evidenced by depressed mood, weight loss, fatigue, and appearing withdrawn, was noted in this patient. Levetiracetam was discontinued by order of the patient's primary care physician. At a follow-up appointment 4 weeks later, the depressive symptoms had nearly resolved. The patient's Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating levetiracetam to be a probable cause of depression in this patient. In a second case, a 92-year-old white woman (height, 154.9 cm; weight, 54.5 kg; BMI, 22.7 kg/m(2)) with existing chronic kidney disease and new-onset partial seizure, likely due to a meningioma, was initiated on levetiracetam 500 mg once daily. Depressive symptoms (eg, anhedonia, hypersomnolence, decre...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jan 5, 2002·The American Journal of Psychiatry·Joseph F Goldberg, Katherine E Burdick
Jul 23, 2003·Journal of Psychopharmacology·Peter Bräunig, Stephanie Krüger
Aug 26, 2003·The Journal of Clinical Psychiatry·Heinz GrunzeJörg Walden
Dec 8, 2004·Epilepsy & Behavior : E&B·Kenneth R Kaufman
Dec 5, 2006·CNS Drugs·Anjana Muralidharan, Zubin Bhagwagar
Nov 23, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marianna MazzaSalvatore Mazza
May 30, 2008·Neurology·M J V PughUNKNOWN Treatment In Geriatric Epilepsy Research (TIGER) team
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Antonio GambardellaAldo Quattrone
Oct 14, 2008·Seizure : the Journal of the British Epilepsy Association·Camille TamarelleStéphane Auvin

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Citations

Jan 14, 2012·Journal of the American Geriatrics Society·Anne RobinsAbul Azim
Jun 22, 2016·Expert Review of Neurotherapeutics·Kaiyan Tao, Xuefeng Wang

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