Probable valproate sodium-associated hypotension

The American Journal of Geriatric Pharmacotherapy
Ken S Ota

Abstract

Valproate sodium, a commonly used antiepileptic drug (AED), is effective for the treatment of status epilepticus and is often used as a second-line agent when other AEDs are contraindicated. Some studies have reported that infusion of valproate sodium is generally well tolerated, whereas other studies have reported various degrees of hypotension during infusion. The objective of this case report was to call attention to the potential risk of hypotension after intravenous infusion of valproate sodium. This was the case of a 75-year-old Hispanic man (height, 145 cm; weight, 68 kg) who developed hypotension after receiving an intravenous loading dose of valproate sodium. The patient received the loading dose 12 hours after administration of his last dose of phenytoin (300 mg daily), which had been discontinued secondary to a cutaneous drug reaction. The patient's medical history was significant for seizure disorder, a cerebrovascular accident, and controlled type 2 diabetes mellitus. He was taking glyburide 5 mg daily and aspirin 81 mg daily. At baseline, the patient's blood pressure (measured while seated, at rest, using an upper-extremity cuff) was 135/70 mm Hg. The intravenous loading dose of valproate sodium (20 mg/kg) was adm...Continue Reading

References

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Feb 27, 2007·Epilepsia·Nita A LimdiEdward Faught

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Citations

Oct 19, 2013·The Journal of Surgical Research·John O HwabejireHasan B Alam
May 21, 2015·Arquivos de neuro-psiquiatria·Hasan Hüseyin ÖzdemirSelçuk İlhan

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