Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung

Clinical Neurology and Neurosurgery
K BruylantP P De Deyn

Abstract

Paraneoplastic cerebellar degeneration (PCD) is the most frequent paraneoplastic syndrome affecting the brain. Until now, anti-Tr associated PCD was only seen in patients with Hodgkin's disease. We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria. Extensive diagnostic approach initially showed no evidence of tumor. The patient was found to have anti-Tr antibodies in his serum. Fourteen months after onset of symptoms a whole body PET-scan showed a pathological focus at the right hilus of the lungs. A mediastinoscopy was performed and peribronchial node sampling was done. The anatomopathological analysis revealed a non-well differentiated squamous cell carcinoma. This is the first report about the association between an anti-Tr associated PCD and squamous cell carcinoma.

References

Sep 1, 1976·Archives of Neurology·J L TrotterC K Osterland
May 1, 1990·Medical Hypotheses·J C Salomon
May 24, 2003·Brain : a Journal of Neurology·Setareh Shams'iliPeter Sillevis Smitt

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Citations

Jun 25, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jessica DayAlpha Tsui
Dec 2, 2004·Auris, Nasus, Larynx·Ken-Ichi WatanabeToshiaki Yagi
Aug 13, 2014·World Journal of Clinical Oncology·Nobuhiro KanajiTakuya Matsunaga
Mar 29, 2014·Expert Review of Clinical Immunology·Chrissa SiokaAthanassios P Kyritsis
Oct 9, 2020·Journal of Clinical Neurology·Xuan SunZhenfu Wang
Nov 25, 2021·The Cerebellum·Igor Gusmão Campana, Guilherme Diogo Silva

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