Probe-based confocal laser endomicroscopy evaluation of colon preneoplastic lesions, with particular attention to the aberrant crypt foci, and comparative assessment with histological features obtained by conventional endoscopy.

Gastroenterology Research and Practice
Massimo MascoloGiovanni D De Palma

Abstract

The colorectal carcinoma represents one of the most common and aggressive malignancies, still characterized by an unacceptable mortality rate, mainly due to the high metastatic potential and to a late diagnosis. In the last years, the research community focused on the chance of improving the endoscopic screening to detect neoplastic lesions in a very early stage. Several studies proposed aberrant colonic crypt foci as the earliest recognizable step of transformation in colonic multiphase carcinogenesis. We previously demonstrated the clinical applicability and predictive power of probe-based confocal laser endoscopy (pCLE) in superficial colorectal neoplastic lesions and also characterized in vivo a case of dysplasia-associated lesional mass (DALM) in ulcerative colitis. Now, we aim to evaluate the accuracy of pCLE in the detection of ACF comparing in double-blind manner the microendoscopic and histopathological features resulting from colonic biopsy. By pCLE, we identified specific crypt architecture modifications associated with changes in cellular infiltration and vessels architecture, highlighting a good correspondence between pCLE features and histology.

References

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Citations

Mar 26, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jeffrey M Marks
Feb 20, 2013·Familial Cancer·Jasmijn F HaanstraJan J Koornstra
Mar 19, 2016·BioMed Research International·Alessandro FugazzaNicola de'Angelis
Nov 22, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Giovanni D De PalmaLuigi Bucci
Apr 18, 2015·BMC Cancer·Giovanni D De PalmaPietro Forestieri
Sep 9, 2017·Journal of Clinical Gastroenterology·Sreekar VennelagantiPrateek Sharma
Jan 28, 2014·Biomedical Optics Express·Nima TabatabaeiGuillermo J Tearney

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Methods Mentioned

BETA
biopsies
biopsy
sedation
confocal endomicroscopy
imaging technique

Software Mentioned

MCE
MIUR
pCLe

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