Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

Biomedical Optics Express
Jules SchollerKate Grieve

Abstract

We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our setups combine high lateral resolution over a large field of view with acquisition at several hundreds of frames per second which make it a promising tool for clinical applications and biomedical studies. Its contactless and non-destructive nature is shown to be effective for both following in vitro sample evolution over long periods of time and for imaging of the human eye in vivo.

References

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Feb 24, 2016·Investigative Ophthalmology & Visual Science·Robin SharmaJennifer J Hunter
Jul 15, 2016·Investigative Ophthalmology & Visual Science·Kate GrieveMichel Paques
Dec 27, 2016·Biomedical Optics Express·Andreas WartakChristoph K Hitzenberger
Feb 15, 2017·Journal of Biomedical Optics·Olivier ThouveninClaude Boccara
Sep 12, 2017·Investigative Ophthalmology & Visual Science·Olivier ThouveninKate Grieve
Mar 20, 2018·Biomedical Optics Express·Viacheslav MazlinA Claude Boccara

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Citations

Jun 6, 2020·Biomedical Optics Express·Hui Min LeungGuillermo J Tearney
May 16, 2019·Biomedical Optics Express·Adrian PodoleanuRishard Weitz
Aug 31, 2020·Light, Science & Applications·Jules SchollerKate Grieve
Oct 6, 2020·Biomedical Optics Express·Pedro MecêClaude Boccara
Nov 6, 2020·Biomedical Optics Express·Denise ValenteRavi S Jonnal
Aug 18, 2021·Light, Science & Applications·Jules SchollerKate Grieve

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