Probing Gas-Phase Clustering Thermodynamics with Ion Mobility-Mass Spectrometry: Association Energies of Phenylalanine Ions with Gas-Phase Alcohols

Journal of the American Society for Mass Spectrometry
Pearl Kwantwi-BarimaBrian H Clowers

Abstract

Vapor assisted mobility shift measurements were made with atmospheric pressure drift tube ion mobility-mass spectrometry (IM-MS) to determine the thermodynamic properties of weakly bound ion-molecule clusters formed from protonated phenylalanine and neutral vapor molecules with hydroxyl functional groups. Relative binding energies and gas-phase association energies of amino acid ions clustered with small organic molecules have been established previously using high pressure mass spectrometry. However, the issue of volatility largely prohibits the use of high pressure mass spectrometry for the determination of gas-phase associations of amino acid ions clustered with neutral vapor molecules in many instances. In contrast, ion mobility measurements can be made at atmospheric pressure with volatile vapor additives near and above their boiling points providing access to clustering equilibria not possible using high vacuum techniques. In this study we report the gas-phase association energies, enthalpies, and entropies for protonated phenylalanine ion clustered with three neutral vapor molecules: 2-propanol, 1-butanol, and 2-pentanol based upon measurements at temperatures ranging from 120 oC to 180 oC. The gas-phase enthalpy and ent...Continue Reading

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