Probing intermolecular hydrogen bonding in sibenadet hydrochloride polymorphs by high-resolution (1) H double-quantum solid-state NMR spectroscopy

Journal of Pharmaceutical Sciences
Jonathan P BradleySteven P Brown

Abstract

Molecular packing in two polymorphs of sibenadet hydrochloride (AR-C68397AA, Viozan™) is investigated using a combined experimental (1) H double-quantum (DQ) solid-state magic-angle spinning nuclear magnetic resonance and computational (gauge including projected augmented wave calculation of chemical shifts) approach. For Form I, NH-NH and NH-OH (1) H DQ peaks are observed corresponding to nearest distances of 2.62 and 2.87 Å, respectively, for the intermolecular hydrogen-bonding arrangement in the single-crystal X-ray diffraction structure. The same (1) H DQ peaks at the same (1) H chemical shifts are observed for Form II, for which there is no single-crystal diffraction structure, indicating the same intermolecular hydrogen-bonding arrangement of the benzothiazolone moieties as in Form I. (1) H DQ build-up (as a function of the DQ recoupling time) curves are presented for the resolved NH-NH and NH-OH DQ peaks for the two polymorphs. For Form I, the ratio of the maximum intensity for the NH-OH and NH-NH DQ peaks is in excellent agreement with the ratio of the summed squares of the H-H dipolar couplings, as determined using H-H distances from the crystal structure up to 4 Å. Small differences in the (1) H DQ build-up behaviour ...Continue Reading

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Citations

May 21, 2014·Pharmaceutical Research·Miguel A RodriguesEdmundo Gomes de Azevedo
Nov 1, 2013·Journal of Pharmaceutical and Biomedical Analysis·Katarzyna Paradowska, Iwona Wawer
Sep 6, 2014·The Journal of Physical Chemistry. a·Pavel V GushchinVadim Yu Kukushkin
May 26, 2018·Physical Chemistry Chemical Physics : PCCP·Helen GrüningerJürgen Senker
Jan 11, 2013·Molecular Pharmaceutics·Andrew S TattonSteven P Brown

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