Probing microenvironment of micelle and albumin using diethyl 6-(dimethylamino)naphthalene-2,3-dicarboxylate: An electroneutral solvatochromic fluorescent probe

Journal of Colloid and Interface Science
Suman MallickApurba L Koner

Abstract

Synthesis, single-crystal X-ray characterization, and spectroscopic investigation of small, non-charged diethyl 6-(dimethylamino)naphthalene-2,3-dicarboxylate (DMNDC) by UV-Visible, steady-state, and time-resolved fluorescence reveal a series of interesting photophysical properties originating from the intrinsic intramolecular charge transfer (ICT) state, leading to diverse applications. Stokes shift, lifetime, and emission maxima of DMNDC show a very good correlation with ET(30) solvent polarity scale for a series of different polarity solvents, confirms that it has very good environment sensitivity. Furthermore, this dye has been found to be an exceptionally suitable probe for determining Critical Micelle Concentration (CMC) and probing self-organization processes of five different type of surfactant with structural diversity. A 20-60nm blue shift in emission maxima accompanied by a large fluorescence lifetime enhancement (ca. 23ns) was observed upon relocation of DMNDC into a hydrophobic microenvironment. Along with this, the small size, electroneutrality, pH stability, and excellent solvatochromic fluorescent properties are employed for deciphering the number of hydrophobic binding pockets with strong affinity and their loc...Continue Reading

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Citations

Mar 13, 2012·Biophysical Journal·Jonathan A FauerbachElizabeth A Jares-Erijman
Jan 26, 2017·Physical Chemistry Chemical Physics : PCCP·Falguni ChandraApurba L Koner
May 5, 2017·Chemistry : a European Journal·Kaushik Pal, Apurba Lal Koner
Sep 1, 2018·Chemical Communications : Chem Comm·Kaushik PalApurba Lal Koner
Apr 7, 2021·Journal of Fluorescence·Helena J SpikesCynthia M Dupureur
Jul 9, 2020·Analytical Chemistry·Anirban DasIshu Saraogi
Oct 30, 2019·Journal of the American Chemical Society·Nickolas A SayresmithMichael G Walter

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