Probing molecular interactions of PEGylated chitosan in aqueous solutions using a surface force apparatus

Physical Chemistry Chemical Physics : PCCP
Li XiangHongbo Zeng

Abstract

PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan play a critical role in forming the core-shell structure of the complexes. In this work, we systematically investigated the cohesive interaction between PEGylated chitosan films using a surface forces apparatus (SFA) under different solution conditions, and the corresponding morphology change was characterized using atomic force microscopy (AFM). The force measurements demonstrated that the cohesion could be enhanced by increasing the contact time and the PEGylation degree, but could be weakened by increasing the solution pH, which is closely related to the morphology change of the PEGylated chitosan films. The strong cohesion of PEGylated chitosan, as compared to that of native chitosan, is primarily attributed to improved polymer solubility and flexibility, and enhanced formation of hydrogen bonds between the polymer chains. In addition, continuously increasing the PEGylation degree was found to be less effective in further strengthen...Continue Reading

References

May 16, 2003·Carbohydrate Research·Amornrat LertworasirikulKozo Ogawa
Jun 5, 2004·International Journal of Biological Macromolecules·Kozo OgawaKenji Okuyama
Feb 17, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·C PregoM J Alonso
Mar 1, 2007·Arthritis and Rheumatism·Tannin A SchmidtRobert L Sah
Jun 19, 2007·Biomaterials·Dong Soo HwangHyung Joon Cha
Oct 18, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Hongbo ZengJacob N Israelachvili
Apr 18, 2009·Toxicology and Applied Pharmacology·Anastasia MalekAchim Aigner
Oct 3, 2009·Angewandte Chemie·Zifu LiTo Ngai
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hongbo ZengJ Herbert Waite
Sep 18, 2010·Journal of Colloid and Interface Science·Zhiguang GuoBao-Lian Su
Sep 30, 2010·Biomacromolecules·Luca CasettariLisbeth Illum
Nov 13, 2010·Colloids and Surfaces. B, Biointerfaces·Marta KocunLouis A Cuccia
May 11, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Hongbo ZengJacob Israelachvili
Aug 27, 2011·Biomacromolecules·Sylvie LéluCatharina de Lange Davies
Nov 8, 2011·Annual Review of Materials Research·Bruce P LeeJ H Waite
Aug 10, 2012·Biochemistry·Eric W DannerJ Herbert Waite
Oct 27, 2012·Journal of Materials Chemistry·Dong Soo HwangJ Herbert Waite
Sep 11, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ali Faghihnejad, Hongbo Zeng
Oct 22, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Dong Woog LeeDong Soo Hwang
Jan 7, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·H RagelleV Préat
Sep 15, 2015·Chemical Communications : Chem Comm·Lin LiHongbo Zeng
Apr 17, 2016·Carbohydrate Polymers·Andra GuţoaiaHanna Hartmann
Nov 17, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vassilis BourganisCostas Kiparissides

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Citations

Sep 15, 2020·Clinical Hemorheology and Microcirculation·Yan NieAndreas Lendlein
Apr 21, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yajing KanYunfei Chen

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Methods Mentioned

BETA
transfection
chemical modification
atomic force microscopy
interaction force measurements
Nuclear Magnetic Resonance
force measurements
AFM
NMR
force measurement
force

Software Mentioned

MestReNova

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