Probing nucleic acid structure with shape-selective rhodium and ruthenium complexes

Current Protocols in Nucleic Acid Chemistry
B A Jackson, J K Barton

Abstract

In this unit, transition metal complexes are used as photochemical probes for the structure of RNA and DNA. The transition metal ion provides a rigid substitutionally inert framework and an octahedral geometry for ligand coordination. The complexes can be constructed to define shapes, symmetries, and functionalities that complement those of the nucleic acid target. Complex formation is easily detected by light-induced nucleic acid cleavage. The modular construction of the complexes makes it possible to generate probes to examine a wide variety of structural characteristics of nucleic acids.

References

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Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H Y Mei, J K Barton
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Jan 1, 1997·Methods in Molecular Biology·W D WilsonC T Rigl
Jan 23, 1998·Psychiatry Research·A R DeshmukhA Pfefferbaum

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