Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

Immunologic Research
J J Siekierka

Abstract

In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V CalvoB E Bierer
Dec 11, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C C TrandinhM H Saier
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G WiederrechtJ J Siekierka
Mar 1, 1991·The Journal of Experimental Medicine·N H SigalS L Koprak
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B E BiererS L Schreiber
Nov 30, 1993·Annals of the New York Academy of Sciences·G WiederrechtN Sigal
Jan 1, 1994·Annual Review of Biochemistry·G R Crabtree, N A Clipstone
May 13, 1993·Nature·H A LaneG Thomas
Jun 18, 1993·Cell·C J Sherr

❮ Previous
Next ❯

Citations

Jan 1, 1996·Annual Review of Immunology·R T Abraham, G J Wiederrecht
Apr 3, 2019·International Journal of Occupational Safety and Ergonomics : JOSE·Joseph FlanneryAdekunle S Oyegoke
Oct 24, 2019·Nanomedicine·Amber Nagy, Nicholas L Robbins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.