PMID: 7539823DOI: 10.1007/bf02918272Jan 1, 1994Paper
Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin
Immunologic Research
J J Siekierka
Abstract
In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.
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Oct 24, 2019·Nanomedicine·Amber Nagy, Nicholas L Robbins
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