Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy.

Protein Science : a Publication of the Protein Society
Jing XuS James Allen

Abstract

Biological polymers are expected to exhibit functionally relevant, global, and subglobal collective modes in the terahertz (THz) frequency range (i.e., picosecond timescale). In an effort to monitor these collective motions, we have experimentally determined the absorption spectrum of solvated bovine serum albumin (BSA) from 0.3 to 3.72 THz (10-124 cm(-1)). We successfully extract the terahertz molar absorption of the solvated BSA from the much stronger attenuation of water and observe in the solvated protein a dense, overlapping spectrum of vibrational modes that increases monotonically with increasing frequency. We see no evidence of distinct, strong, spectral features, suggesting that no specific collective vibrations dominate the protein's spectrum of motions, consistent with the predictions of molecular dynamics simulations and normal mode analyses of a range of small proteins. The shape of the observed spectrum resembles the ideal quadratic spectral density expected for a disordered ionic solid, indicating that the terahertz normal mode density of the solvated BSA may be modeled, to first order, as that of a three-dimensional elastic nanoparticle with an aperiodic charge distribution. Nevertheless, there are important det...Continue Reading

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B Brooks, M Karplus
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N GoT Nishikawa
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B Brooks, M Karplus
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jorge PeonAhmed H Zewail
Nov 28, 2002·Physics in Medicine and Biology·Andrea MarkelzRobert Birge
Nov 28, 2002·Physics in Medicine and Biology·B M FischerP Uhd Jepsen
Jul 28, 2004·Journal of the American Society for Mass Spectrometry·Bill X HuangChhabil Dass
Dec 9, 2004·Physics in Medicine and Biology·Gillian C WalkerDavid S Brettle
Jan 28, 2006·The Journal of Chemical Physics·Jing XuS James Allen
Nov 1, 1967·Applied Optics·C M Randall, R D Rawcliffe
Jun 1, 1975·Applied Optics·D R Smith, E V Loewenstein
Jun 1, 2003·Journal of Biological Physics·T R GlobusA C Samuels
Jun 1, 2003·Journal of Biological Physics·A J FitzgeraldM A Smith
Jun 1, 2003·Journal of Biological Physics·R M WoodwardM Pepper

❮ Previous
Next ❯

Citations

Feb 4, 2009·Journal of Molecular Modeling·Saravana Prakash Thirumuruganandham, Herbert M Urbassek
May 14, 2009·HFSP Journal·David M LeitnerMartina Havenith
Dec 27, 2012·The Journal of Chemical Physics·Matthias HeydenDmitry V Matyushov
Dec 18, 2013·The Journal of Chemical Physics·Paola SassiAssunta Morresi
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Simon EbbinghausMartina Havenith
Jun 11, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard Neutze
Jan 3, 2016·The Review of Scientific Instruments·Deepu K GeorgeN Q Vinh
Mar 17, 2016·The Journal of Physical Chemistry Letters·Daniël J BakkerAnouk M Rijs
Jul 24, 2014·IEEE Journal of Biomedical and Health Informatics·Caroline B ReidVincent P Wallace
Dec 1, 2009·Biochemical and Biophysical Research Communications·Rui LiuZhimin He
Feb 24, 2015·Journal of Biological Physics·P Glancy
Aug 30, 2014·The Journal of Physical Chemistry. B·Bertil Halle
Dec 18, 2013·The Journal of Physical Chemistry. a·Jordan W ByeRobert J Falconer
Mar 2, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Dipak Kumar DasRajib Kumar Mitra
Jul 7, 2017·Chemical Communications : Chem Comm·Youssef El Khoury, Petra Hellwig
Jun 27, 2017·IEEE Transactions on Nanobioscience·Hadeel ElayanPedram Johari
Nov 9, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·David F PlusquellicOkan Esenturk
Jun 17, 2008·Physics in Medicine and Biology·H YoneyamaT Ouchi
Apr 21, 2010·Physical Chemistry Chemical Physics : PCCP·Yutaka NagasawaShun Hirota
Jun 10, 2010·Journal of Biophotonics·Changlei WangAleksei M Zheltikov
Sep 26, 2017·Physics in Medicine and Biology·Yuezhi HeEmma PickWell-MacPherson
Nov 30, 2016·Biomedical Optics Express·Yan PengYiming Zhu
Sep 3, 2017·The Journal of Chemical Physics·Daniel R Martin, Dmitry V Matyushov
Mar 16, 2018·Biomedical Optics Express·Bao C Q TruongVincent P Wallace
Sep 3, 2020·The Review of Scientific Instruments·S SchewaM Roessle
Nov 28, 2008·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Vincent P WallaceCaroline Reid
Dec 7, 2011·Chemical Society Reviews·Alexander I McIntoshRobert S Donnan
Mar 30, 2017·Interdisciplinary Sciences, Computational Life Sciences·Su-Qin ZhouEn-Ren Wang
May 8, 2018·Journal of Biological Physics·Z V GagkaevaB P Gorshunov
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Longteng TangChong Fang
Apr 22, 2020·Annual Review of Physical Chemistry·Christopher M Cheatum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.