Probing the Effects of Heterocyclic Functionality in [(Benzene)Ru(TsDPENR)Cl] Catalysts for Asymmetric Transfer Hydrogenation

Organic Letters
Jonathan Barrios-RiveraMartin Wills

Abstract

A range of TsDPEN catalysts containing heterocyclic groups on the amine nitrogen atom were prepared and evaluated in the asymmetric transfer hydrogenation of ketones. Bidentate and tridentate ligands demonstrated a mutual exclusivity directly related to their function as catalysts. A broad series of ketones were reduced with these new catalysts, permitting the ready identification of an optimal catalyst for each substrate and revealing the subtle effects that changes to nearby donor groups can exhibit.

References

Oct 27, 2007·Accounts of Chemical Research·Takao Ikariya, A John Blacker
Jun 11, 2015·Chemical Reviews·Dong Wang, Didier Astruc
Mar 22, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Pavel A Dub, John C Gordon
Aug 11, 2016·Journal of the American Chemical Society·Taichiro Touge, Takayoshi Arai
Jan 12, 2019·Organic & Biomolecular Chemistry·Jonathan Barrios-RiveraMartin Wills

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