Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice

Environmental Epigenetics
Johannes BohacekIsabelle M Mansuy

Abstract

We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery,in vitroculture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspring.

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Citations

Mar 1, 2017·Nature Methods·Johannes Bohacek, Isabelle M Mansuy
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ulrike Weber-StadlbauerUrs Meyer
Jul 27, 2020·Environmental Epigenetics·Corrado Spadafora

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