Probiotic (Enterococcus faecium) induced responses of the hepatic proteome improves metabolic efficiency of broiler chickens (Gallus gallus)

BMC Genomics
Aijuan ZhengBin Yao

Abstract

The liver plays important roles in nutrient metabolism, detoxification and immunity. Enterococcus faecium (E. faecium) is a probiotic that has been shown to have positive effects on broiler production. However, its molecular effects on liver metabolism have not been characterized. This study aims to further identify the biological roles of E. faecium by characterizing the hepatic proteomic changes of broilers (Gallus gallus) fed E. faecium using two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) and mass spectrometry (MS). Thirty-three proteins (50 protein spots) involved in nutrient metabolism, immunity and the antioxidant system were shown to be differentially expressed in the liver of broilers fed E. faecium than from birds not fed the probiotic. The biological processes of sulphur amino acids, vitamin and cellular hormone metabolism, sulphur compound biosynthesis and protein tetramerization were enhanced in the liver of broilers fed E. faecium. However, proteins involved in calcium ion flux, cell redox homeostasis and platelet activation related to hepatic immune responses were down-regulated in broilers fed E. faecium. These results indicate that the supplementation of poultry feed with E. faecium may a...Continue Reading

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Citations

Sep 15, 2018·Journal of Animal Science and Biotechnology·Marco ZampigaFederico Sirri
Feb 23, 2019·Frontiers in Microbiology·Mark Alan Frank GillinghamSimone Sommer
Jun 27, 2019·BioMed Research International·Olfa Ben Braïek, Slim Smaoui
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Methods Mentioned

BETA
electrophoresis
interaction prediction
PCR
acetylation
ubiquitination

Software Mentioned

STRING
Mass Hunter
DeCyder
Mascot Distiller
Search Tool for
DeCyder Differential Analysis
IQTM5
Mascot
ClueGo
BLAST

Related Concepts