Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs

Mediators of Inflammation
Yingdi ZhangHongjie Zhang

Abstract

Bifico is a probiotic mixture containing Bifidobacterium, Lactobacillus acidophilus, and Enterococcus. Studies support that Bifico has a protective effect in experimental colitis (IL-10-deficient and TNBS) models and in patients with inflammatory bowel disease (IBD). However, the mechanism underlying the protective effects of this mixture of probiotic bacteria remains incompletely clear. Here, we investigated the effect of Bifico on intestinal inflammation. In an in vivo experiment, dextran sulfate sodium was used to induce colitis. Bifico treatment significantly attenuated the severity of colitis in this model. Bifico increased the expression of tight junction proteins (TJs). In addition, Bifico increased the number of Tregs, but reduced the number of total CD4+ T cells in the peripheral blood. Furthermore, the expression of colonic CD4 protein was decreased while the level of forkhead box P3 (Foxp3) was upregulated. These results suggested that Bifico exerts beneficial effects on experimental colitis by increasing the expressions of TJs, upregulating the number of Tregs, and reducing the total CD4+ T cell number in both colon and peripheral blood. The intestinal damage in the pretreated + treated-Bifico-colitis group was more...Continue Reading

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Citations

Mar 1, 2020·Applied Microbiology and Biotechnology·Jean Guy LeBlancAlejandra de Moreno de LeBlanc
Dec 27, 2019·International Immunopharmacology·Lucia Malaguarnera
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Yean Leng LokeSuat Cheng Peh
Jan 1, 2021·BioMed Research International·Xin WangQing-Zhi He
Apr 8, 2021·Environmental Chemistry Letters·Han DaiEric Lichtfouse

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

Bifico
ImageLab2
SPSS

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