Probiotic Pediococcus pentosaceus strain GS4 alleviates azoxymethane-induced toxicity in mice

Nutrition Research
Vinay DubeyAnisur R Khuda-Bukhsh

Abstract

Probiotic treatment has been gaining attention due to its remarkable effects in alleviating toxicity and carcinogenesis. The novel strain Pediococcus pentosaceus GS4 has been reported for probiotic, survivability in simulated gastrointestinal fluid, and antioxidative and biohydrogenation properties. Therefore, we hypothesize that this specific strain might be able to assuage the effect of azoxymethane (AOM)-induced toxicity in mice. Twenty-eight Swiss albino mice were divided into 4 groups and were studied for 32 weeks. Azoxymethane (10 mg/kg body weight) was administered intraperitoneally twice (0th and 14th days), and probiotic GS4 (1.1 × 10(9) colony-forming unit/mL) was given orally for the respective groups. Mice who served as the normal control received only normal saline. GS4-intervened AOM-induced mice showed marked improvement at the histopathologic level, in the liver and kidney. Moreover, probiotic GS4 intervention in AOM-induced mice exhibited a significant reduction in the liver function biomarker when compared with the AOM-induced mice. Probiotic GS4 intervention reduced the intestinal structural deformities as evident from the elevated brush border membrane-associated disaccharidases (sucrase, lactase) and intest...Continue Reading

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Citations

Jan 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Robert A RothPatricia E Ganey
Mar 19, 2019·Molecular Nutrition & Food Research·Yue-Bang YinYu-Long Yin
Feb 24, 2019·Folia Microbiologica·Budhaditya GhoshAsit Ranjan Ghosh
Feb 18, 2021·Microbial Cell Factories·Shiman JiangLanjuan Li

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