Probiotic Pre-treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats

Archives of Drug Information
Hani Al-SalamiMomir Mikov


AIM: To investigate the influence of probiotic pre-treatment on the permeation of the antidiabetic drug gliclazide in healthy and diabetic rats. METHODS: Wistar rats (age 2-3 months, weight 350 +/- 50 g) were randomly allocated into one of 4 groups (N = 16 each group): healthy control, healthy probiotic, diabetic control, and diabetic probiotic. Probiotics (75 mg/kg, equal quantities of Lactobacillus acidophilus, Bifidobacterium lactis, and Lactobacillus rhamnosus) were administered twice a day for three days to the appropriate groups after diabetes had been induced with alloxan i.v. 30 mg/kg. Rats were sacrificed, ileal tissues mounted in Ussing chambers and gliclazide (200 microg/mL) was administered for the measurement of the mucosal to serosal absorption Jss((MtoS)) and serosal to mucosal secretion Jss((StoM)) of gliclazide. RESULTS: Treatment of healthy rats with probiotics reduced Jss((MtoS)) of gliclazide from 1.2 +/- 0.3 to 0.3 +/- 0.1 microg/min/cm(2) (P < 0.01) and increased Jss((StoM))from 0.6 +/- 0.1 to 1.4 +/- 0.3 (P < 0.01) resulting in net secretion while, in diabetic tissues, treatment with probiotics increased both Jss((MtoS)) and Jss((StoM))fluxes of gliclazide to the comparable levels of healthy tissues resul...Continue Reading


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Oct 12, 2012·Applied Biochemistry and Biotechnology·Nebojša PavlovićMomir Mikov
Jan 21, 2016·Food & Function·Ram Mohan ThusharaMohammed H Moghadasian
Jan 23, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Zuzana MatuskovaEva Anzenbacherova
Nov 26, 2015·Journal of Pharmacological and Toxicological Methods·Miroslav RadenkovićMilica Prostran
May 15, 2013·Journal of Diabetes Research·Mladena Lalić-PopovićMomir Mikov
Dec 12, 2012·Diabetes/metabolism Research and Reviews·Harsh PanwarSunita Grover
Oct 19, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Momir MikovHani Al-Salami
Jul 1, 2020·Expert Opinion on Drug Delivery·Susbin Raj WagleHani Al-Salami
Apr 2, 2019·Frontiers in Nutrition·Veronica LazarMariana Carmen Chifiriuc
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Nov 20, 2020·Food & Function·Amalia E YanniVaios T Karathanos
Dec 11, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maja ĐanićMomir Mikov

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