Probiotic Product Enhances Susceptibility of Mice to Cryptosporidiosis

Applied and Environmental Microbiology
Bruno C M Oliveira, Giovanni Widmer

Abstract

Cryptosporidiosis, a leading cause of diarrhea among infants, is caused by apicomplexan parasites classified in the genus Cryptosporidium The lack of effective drugs is motivating research to develop alternative treatments. With this aim, the impact of probiotics on the course of cryptosporidiosis was investigated. The native intestinal microbiota of specific pathogen-free immunosuppressed mice was initially depleted with orally administered antibiotics. A commercially available probiotic product intended for human consumption was subsequently added to the drinking water. Mice were infected with Cryptosporidium parvum oocysts. On average, mice treated with the probiotic product developed more severe infections. The probiotics significantly altered the fecal microbiota, but no direct association between ingestion of probiotic bacteria and their abundance in fecal microbiota was observed. These results suggest that probiotics indirectly altered the intestinal microenvironment or the intestinal epithelium in a way that favored proliferation of C. parvumIMPORTANCE The results of our study show that C. parvum responded to changes in the intestinal microenvironment induced by a nutritional supplement. This outcome paves the way for r...Continue Reading

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Citations

May 8, 2019·Nature Medicine·Jotham SuezEran Elinav
Mar 14, 2020·Parasite : Journal De La Société Française De Parasitologie·Giovanni WidmerLoïc Favennec
Sep 29, 2019·PLoS Neglected Tropical Diseases·Bruno César Miranda OliveiraGiovanni Widmer
Aug 5, 2020·Parasitology Research·Dalia S Ashour, Ahmad A Othman
Jul 28, 2019·Trends in Parasitology·Sonja RueckertAnastasios D Tsaousis
Jan 28, 2021·Animal Microbiome·Bruno C M OliveiraGiovanni Widmer
Dec 23, 2020·Microorganisms·Aly KodioStéphane Ranque
Jan 19, 2019·Trends in Microbiology·Chung-Yin Leung, Joshua S Weitz
Mar 9, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maureen A CareyCarol A Gilchrist

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