Probiotic supplementation and associated infant gut microbiome and health: a cautionary retrospective clinical comparison

Scientific Reports
C QuinD L Gibson

Abstract

While probiotics are a multi-billion dollar industry, there is little evidence to show that supplementing infants provides any health benefits. We conducted an observational study where 35 of 86 participating mothers self-administered probiotics during breastfeeding, as well as directly to their infants. The primary objective was to determine if probiotic exposure influenced the infants' fecal microbiome while the secondary objective assessed associated changes to the mothers' breast milk immunity and infant health. Analysis of infant fecal microbiome throughout the first 6 months of life revealed that probiotics were associated with higher abundances of Bifidobacterium at week 1 only. Short-chain fatty acid production and predicted metagenomic functions of the microbial communities were not altered. While probiotics did not alter breast milk immune markers, fecal sIgA responses were higher among probiotic supplemented infants. Surprisingly, this was not associated with better health outcomes, as the probiotic cohort had higher incidences of mucosal-associated illnesses as toddlers. This retrospective clinical comparison suggests that probiotic exposure during infancy has limited effects on gut microbial composition yet is asso...Continue Reading

Associated Clinical Trials

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Citations

Nov 18, 2018·Gut Microbes·Jacqueline A Barnett, Deanna L Gibson
May 8, 2019·Nature Medicine·Jotham SuezEran Elinav
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Methods Mentioned

BETA
amplicon sequencing
PCR
Electrophoresis

Clinical Trials Mentioned

NCT03297801

Software Mentioned

FastTree2
QIIME
PERMANOVA
MAFFT
GraphPad Prism
ANCOM
Vegan
Greengenes
PICRUSt
R

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