Probiotic supplementation increases obesity with no detectable effects on liver fat or gut microbiota in obese Hispanic adolescents: a 16-week, randomized, placebo-controlled trial

Pediatric Obesity
R B JonesM I Goran

Abstract

Numerous studies have shown that there are links between obesity, liver fat and the gut microbiome. However, there are mixed results on whether probiotics could impact the gut microbiome and/or help to decrease liver fat and obesity outcomes. This study aimed to determine whether a probiotic supplement (VSL#3® ) intervention altered gut microbiota and/or gut hormones associated with appetite regulation. The secondary aim of this study was to determine whether VSL#3® altered body composition and liver fat and fibrosis. We conducted a double-blind, randomized placebo-controlled trial in 19 obese Latino adolescents. The intervention consisted of three packets per day of VSL#3® or a matched placebo for 16 weeks. Pre-intervention and post-intervention measures included gut microbial abundance, gut appetite regulating hormones, anthropometrics, body composition, liver fat and liver fibrosis. We conducted linear models to determine whether there were any significant differences in the changes in these outcomes following VSL#3® intervention. Compared with placebo, adolescents that received VSL#3 had significant increases in total adiposity (%) (+1.7 ± 0.6 vs. -1.3 ± 0.5, p < 0.01) and trunk adiposity (%) (+3.3 ± 0.8 vs. -1.8 ± 0.8, p <...Continue Reading

References

Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Apr 4, 2000·European Journal of Clinical Nutrition·L Agerholm-LarsenA Astrup
Aug 2, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael de VreseJürgen Schrezenmeir
Jul 6, 2006·Applied and Environmental Microbiology·T Z DeSantisG L Andersen
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Rubén E Quirós-TejeiraNancy F Butte
Mar 27, 2009·The Journal of Nutrition·Emanuela EspositoRosaria Meli
Apr 22, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Gavitt A WoodardJohn M Morton
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·J Gregory CaporasoRob Knight
Sep 1, 2008·Obesity Research & Clinical Practice·Mamoru TanidaKatsuya Nagai
Jun 6, 2014·Nature·Rachel J PerryGerald I Shulman
Jul 8, 2015·Clinical Biochemistry·Irina A KirpichCraig J McClain
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Feb 13, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xiaolin GaoChaomin Wan
Apr 5, 2016·International Journal of Molecular Sciences·Mariana Verdelho Machado, Helena Cortez-Pinto
Aug 2, 2016·JAMA Pediatrics·Kimberly P NewtonUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network

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Citations

Jun 13, 2019·Nutrition Reviews·Johnny G SantosValesca Dall'Alba
Mar 12, 2020·Critical Reviews in Food Science and Nutrition·Tatiane Ferreira da SilvaAna Lúcia Barretto Penna
Jun 20, 2020·FEMS Microbiology Reviews·Francesca De FilippisDanilo Ercolini
Nov 6, 2018·Nutrients·Andrea BrusaferroSusanna Esposito
Feb 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gabriella V HernandezRodrigo Manjarin
Jan 27, 2019·Nutrients·Kiran MazloomMihai Covasa
Nov 11, 2019·Nutrients·Ludovico AbenavoliRaffaele Capasso
Jan 27, 2019·Cellular and Molecular Life Sciences : CMLS·Zahra Safari, Philippe Gérard
Mar 3, 2021·European Journal of Nutrition·Yasaman GhorbaniJohane P Allard
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Ayfer Beyaz Coşkun, Adviye Gülçin Sağdiçoğlu Celep
May 21, 2021·Current Hypertension Reports·Piotr DubinskiAgnieszka Cudnoch-Jedrzejewska
Jul 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Arianna SolitoFlavia Prodam
Aug 7, 2021·Medicina·Jernej Brecelj, Rok Orel

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