Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pylori therapy: A randomized, double-blind, placebo-controlled trial

Helicobacter
Adrián G McNichollJavier P Gisbert

Abstract

To evaluate the safety, tolerability and efficacy of a probiotic supplementation for Helicobacter pylori (H. pylori) eradication therapy. Consecutive adult naive patients with a diagnosis of H. pylori infection who were prescribed eradication therapy according to clinical practice (10-day triple or nonbismuth quadruple concomitant therapy) randomly received probiotics (1 × 109 colony-forming units each strain, Lactobacillus plantarum and Pediococcus acidilactici) or matching placebo. Side effects at the end of the treatment, measured through a modified De Boer Scale, were the primary outcome. Secondary outcomes were compliance with therapy and eradication rates. A total of 209 patients (33% triple therapy, 66% non-bismuth quadruple therapy) were included [placebo (n = 106) or probiotic (n = 103)]. No differences were observed regarding side effects at the end of the treatment between groups (β -0.023, P 0.738). Female gender (P < 0.001) and quadruple therapy (P 0.007) were independent predictors of side effects. No differences in compliance were observed, regardless of the study group or eradication therapy. Eradication rates were similar between groups [placebo 95% (95% confidence interval (CI), 89% to 98%) vs probiotic 97% (9...Continue Reading

References

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Citations

Mar 5, 2019·Current Pharmaceutical Biotechnology·Kashyapi Chakravarty, Smriti Gaur
Feb 13, 2020·International Journal of Molecular Sciences·Jianfu Ji, Hong Yang
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Mar 7, 2020·Anaesthesia and Intensive Care·Kwok M HoEdward Litton
Jan 6, 2019·Applied Microbiology and Biotechnology·Nuzhat QureshiQing Gu
Nov 12, 2018·Current Treatment Options in Gastroenterology·Peter MalfertheinerChristian Schulz
Feb 14, 2021·Microorganisms·Natalia Garcia-GonzalezAldo Corsetti

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