Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage.

PloS One
Fernando E García-ArroyoL Gabriela Sánchez-Lozada

Abstract

Hyperuricemia is highly prevalent and especially common in subjects with metabolic, cardiovascular and renal diseases. In chronic kidney disease, hyperuricemia is extremely common, and uric acid (UA) excretion relies on gut uricolysis by gut microbiota. Current therapy for lowering serum UA includes drugs that may produce undesired secondary effects. Therefore, this pilot study was designed to evaluate the potential of two probiotic supplements to reduce systemic uric acid concentrations. Secondary objectives were to assess whether the hypouricemic effect related to a therapeutic benefit on the hyperuricemia-induced renal damage and hypertension. Analysis of fecal microbiota was also performed. Groups of 6 rats each were followed for 5 weeks and allocated in the following treatment groups: C = Control; HU-ND = Oxonic acid-induced hyperuricemia (HU) +regular diet; HU-P = HU+placebo; HU-F1 = HU+ probiotics formula 1 and HU-F2 = HU+ probiotics formula 2. We confirmed that oxonic acid-induced hyperuricemia produced hypertension and renal functional and structural changes, along with modest changes in the overall composition of fecal microbiota. Both probiotic-containing diets prevented HU, elevated UA urinary excretion and intraren...Continue Reading

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Citations

Aug 2, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daxing XuShichao Xing
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Sep 26, 2020·Renal Failure·Tadej PetreskiSebastjan Bevc

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Datasets Mentioned

BETA
PRJNA449940

Methods Mentioned

BETA
PCR

Software Mentioned

R vegan package
Explicet
phrap
R
SINA
PERMANOVA
bowtie2

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