PMID: 15220676Jun 29, 2004Paper

Probiotics: a potential target for the prevention and treatment of steatohepatitis

Journal of Clinical Gastroenterology
Gerardo Nardone, Alba Rocco

Abstract

The accumulation of fat in hepatocytes with a necroinflammatory component-steatohepatitis-that may or may not have associated fibrosis is becoming a frequent lesion. Although steatohepatitis is currently recognized to be a leading cause of cryptogenic cirrhosis, the pathogenesis has not been fully elucidated. Among the various factors implicated, intestinal bacterial overgrowth may play a role. Indeed, various rat models of intestinal bacterial overgrowth have been associated with liver lesions similar to NASH, and bacterial overgrowth has been observed significantly more often in patients with NASH compared with control subjects. The authors discuss the relationship among intestinal bacterial overgrowth, steatohepatitis development, and probiotic treatment.

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Citations

Oct 9, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Nahum Méndez-SánchezMisael Uribe
Jan 10, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Jill A ParnellRaylene A Reimer
Jun 13, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·S F SolgaT H Risby
Jun 9, 2015·World Journal of Hepatology·Fátima Higuera-de la Tijera, Alfredo I Servín-Caamaño
Oct 1, 2014·Alimentary Pharmacology & Therapeutics·E B Mitchel, J E Lavine
Aug 9, 2007·The American Journal of Clinical Nutrition·Angela M ZivkovicArun J Sanyal
Jul 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Radhakrishna Rao
Aug 1, 2021·Clinical Nutrition ESPEN·Farnush Bakhshimoghaddam, Mohammad Alizadeh
Jun 6, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A FedericoC Loguercio

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