Probiotics and neonatal intestinal infection

Current Opinion in Infectious Diseases
Cathy Hammerman, Michael Kaplan

Abstract

Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role of gut microbial colonization and its 'normalization' with probiotics vis a vis its contribution to intestinal bacterial invasion. Recent studies have demonstrated that prophylactic administration of probiotics to preterm neonates decreases both the incidence and severity of subsequent necrotizing enterocolitis. Probiotics represent a therapeutic effort to bolster natural host defenses via the 'normalization' of abnormal gut microflora of the premature infant at risk, thereby reducing the subsequent threat of necrotizing enterocolitis. The appeal of probiotics in neonatology is threefold. First, their safety record renders them an attractive alternative to many of the more aggressive therapeutic options; second, they represent a simple, noninvasive attempt to recreate a natural or normal flora rather than a disruption of nature. Third, probiotics are used mainly for disease prevention and are naturally occurring. As such, they are n...Continue Reading

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Citations

May 15, 2013·International Journal of Antimicrobial Agents·Maria TheodorakopoulouGeorge Dimopoulos
Feb 22, 2012·Current Opinion in Critical Care·Lee E MorrowMark A Malesker
Jan 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·C WiechersC F Poets
Jun 3, 2009·International Journal of Food Microbiology·Franco J Pagotto, Jeffrey M Farber
Jan 31, 2009·International Journal of Antimicrobial Agents·Evridiki K VouloumanouMatthew E Falagas
Nov 3, 2007·Seminars in Fetal & Neonatal Medicine·Nicholas D Embleton, Rowena Yates
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Feb 19, 2008·Clinics in Perinatology·Pinchi S SrinivasanAntoni D'Souza
Apr 4, 2015·Journal of Pediatric Surgery·Frances Lilian Lanhellas GonçalvesLourenço Sbragia
Jan 15, 2014·The Journal of Pediatrics·Annie JanvierKeith J Barrington
Feb 9, 2007·Neonatal Network : NN·Susan Givens Bell
Jan 22, 2008·International Journal of Food Microbiology·Raquel F LenatiFranco J Pagotto
Jul 9, 2008·Journal of Pediatric Gastroenterology and Nutrition·Pinaki PanigrahiIra H Gewolb

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