Probiotics and nutraceuticals as a new frontier in obesity prevention and management

Diabetes Research and Clinical Practice
N KobyliakL Ostapchenko

Abstract

The beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats. Totally, 75 rats divided into five groups were included (n = 15, in each). Rats in group I were intact. Newborn rats in groups II-V were injected with MSG. Group III (Symbiter) received 2.5 ml/kg of multiprobiotic "Symbiter" containing concentrated biomass of 14 probiotic bacteria genera. Groups IV (Symbiter-Omega) and V (Symbiter-Smectite) received a combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5%) or smectite gel (250 mg), respectively. In all interventional groups, significant reductions of total body and visceral adipose tissue weight as compared to MSG-obesity were observed. However, the lowest prevalence of obesity was noted for Symbiter-Omega (20% vs 33.3% as compared to other interventional groups). Moreover, supplementation of probiotics with omega...Continue Reading

Citations

Jun 13, 2019·Nutrition Reviews·Johnny G SantosValesca Dall'Alba
Mar 12, 2020·Critical Reviews in Food Science and Nutrition·Tatiane Ferreira da SilvaAna Lúcia Barretto Penna
Mar 21, 2020·Panminerva Medica·Oleksandr KorotkyiLiudmila Ostapchenko
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Nazarii KobyliakLiudmila Ostapchenko
Oct 14, 2018·Pharmaceuticals·Ludovico AbenavoliNazarii Kobyliak
Mar 21, 2019·World Journal of Diabetes·Yevheniia KyriachenkoNazarii Kobyliak
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
Nov 21, 2020·Minerva endocrinologica·Ludovico AbenavoliNazarii Kobyliak
Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali OsmanMahmoud Sitohy

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