PMID: 16633130Apr 25, 2006Paper

Probiotics for children: use in diarrhea

Journal of Clinical Gastroenterology
Stefano Guandalini

Abstract

The use of probiotics in diarrheal diseases of children is increasing. Probiotics, mostly lactic acid bacteria such as Lactobacilli and Bifidobacteria, but also the yeast Saccharomyces boulardii, have been tried in many double-blinded, randomized, placebo-controlled studies, and several well-conducted meta-analyses are now available. There is some evidence of efficacy in the prevention of community-acquired and nosocomial diarrhea. More solid evidence of efficacy is found in the treatment of sporadic, infectious diarrhea, where several probiotics, and especially Lactobacillus GG, have been found capable of reducing by approximately 1 day the duration of diarrhea, shorten the initial phase of watery stools, and reducing hospital stay in developed countries. The effect is best documented in viral diarrheas. Although there are valid conceptual premises for probiotics to be helpful in inflammatory bowel diseases, only 1 trial has been published in children, showing Lactobacillus GG not to be superior to placebo in maintaining remission of Crohn disease. All considered, more research is needed for a better understanding of the role of probiotics in gastrointestinal diseases of children, addressing issues such as pharmacokinetics, me...Continue Reading

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Citations

Aug 19, 2007·Journal of Clinical Gastroenterology·Sriparna BasuPranab Kumar Chandra
Sep 7, 2007·Journal of Paediatrics and Child Health·Sriparna BasuPranab K Chandra
Aug 27, 2009·Biologics : Targets & Therapy·Satya Prakash, Aleksandra Malgorzata Urbanska
Jan 31, 2009·Nutrition Reviews·Ilja TrebichavskyIgor Splichal
Feb 26, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Paolo AureliGian Vincenzo Zuccotti
Dec 7, 2007·Pediatric Clinics of North America·Benjamin KliglerAndreas Cohrssen
Oct 31, 2015·Future Microbiology·Mohsin KhurshidMuhammad Hidayat Rasool
Dec 11, 2007·International Immunopharmacology·Ma Auxiliadora Dea-AyuelaFrancisco Bolás-Fernandez
Apr 5, 2008·The Journal of International Medical Research·G V ZuccottiM Giovannini
May 22, 2008·Journal of Pediatric Gastroenterology and Nutrition·Ramadass BalamuruganBalakrishnan S Ramakrishna
Nov 28, 2013·Journal of Pediatric Gastroenterology and Nutrition·Fangning LiuLijuan Yuan

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