Probiotics for maintaining remission of ulcerative colitis in adults

The Annals of Pharmacotherapy
Vi T DoDenise R Kockler

Abstract

To evaluate evidence for probiotic efficacy for maintaining remission of ulcerative colitis (UC) in adults. A MEDLINE search (1948-November 2009) was conducted using ulcerative colitis and probiotics as terms for identifying pertinent studies. Search limits included English language and humans. Additional information was obtained from bibliographies. Prospective trials published in English and conducted in adults were included. Two open-label and 3 double-blind randomized trials evaluated probiotic efficacy for maintaining remission of UC. Clinical and surrogate markers for maintaining remission of UC were assessed. A relationship between immune response and gastrointestinal microbials appears to be involved in the mechanism of UC. Trial results comparing the probiotic Escherichia coli Nissle 1917 to mesalazine have reported equivalent rates of UC relapse. Treatment with Lactobacillus rhamnosus GG strain alone or in combination with mesalazine resulted in a nonsignificant odds ratio decrease for relapse and a significant increase in time to relapse compared to treatment with mesalazine alone. Additionally, bifidobacteria-fermented milk-supplemented patients had significant reductions in UC exacerbations when compared to nonsupp...Continue Reading

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Citations

May 10, 2011·Drug Design, Development and Therapy·John K TriantafillidisFilippos Georgopoulos
Oct 26, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Balakrishnan S RamakrishnaUNKNOWN Indian Society of Gastroenterology Task Force on Inflammatory Bowel Diseases
Oct 13, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I-Chiao LeePeter A Bron
Feb 1, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Ronald L Koretz
Aug 29, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sang Kil LeeWon Ho Kim
Nov 22, 2011·Nature Reviews. Microbiology·Peter A BronMichiel Kleerebezem
Mar 5, 2020·The Cochrane Database of Systematic Reviews·Zipporah Iheozor-EjioforAnthony K Akobeng

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