Probiotics for maintenance of remission in ulcerative colitis.

The Cochrane Database of Systematic Reviews
Zipporah Iheozor-EjioforAnthony K Akobeng

Abstract

Ulcerative colitis is an inflammatory condition affecting the colon, with an annual incidence of approximately 10 to 20 per 100,000 people. The majority of people with ulcerative colitis can be put into remission, leaving a group who do not respond to first- or second-line therapies. There is a significant proportion of people who experience adverse effects with current therapies. Consequently, new alternatives for the treatment of ulcerative colitis are constantly being sought. Probiotics are live microbial feed supplements that may beneficially affect the host by improving intestinal microbial balance, enhancing gut barrier function and improving local immune response. The primary objective was to determine the efficacy of probiotics compared to placebo, no treatment, or any other intervention for the maintenance of remission in people with ulcerative colitis. The secondary objective was to assess the occurrence of adverse events associated with the use of probiotics. We searched CENTRAL, MEDLINE, Embase, and two other databases on 31 October 2019. We contacted authors of relevant studies and manufacturers of probiotics regarding ongoing or unpublished trials that may be relevant to the review, and we searched ClinicalTrials....Continue Reading

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Citations

Jul 18, 2020·The Cochrane Database of Systematic Reviews·Berkeley N LimketkaiAkinlolu Adedayo Adepoju
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Ryan SalvadorRachel R Caspi
Mar 16, 2021·Frontiers in Immunology·Fernanda CristoforiRuggiero Francavilla
Feb 3, 2021·Intestinal research·Nor Hamizah ShafieeRaja Affendi Raja Ali
Jul 3, 2021·Nutrients·Leontien Depoorter, Yvan Vandenplas

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