Probiotics for respiratory tract infections in children attending day care centers-a systematic review

European Journal of Pediatrics
Rikke Pilmann Laursen, Iva Hojsak

Abstract

Probiotics have been suggested to have a preventive effect on respiratory tract infections (RTIs), but limited evidence exist on strain-specific effects. The main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on RTIs in children attending day care. We included 15 RCTs with 5121 children in day care settings (aged 3 months to 7 years), but due to high diversity in reported outcomes, different number of RCTs were available for evaluated outcomes. Twelve RCTs (n = 4527) reported results which could be compared in at least one outcome of the meta-analysis. Compared to placebo, Lactobacillus rhamnosus GG (LGG) significantly reduced duration of RTIs (three RCTs, n = 1295, mean difference - 0.78 days, 95% confidence interval (CI) - 1.46; - 0.09), whereas no effect was found on other evaluated outcomes. Based on the results from two studies (n = 343), Bifidobacterium animalis subsp. lactis BB-12 showed no effect on duration of RTIs or on absence from day care. Meta-analyses on other strains or their combination were not possible due to limited data and different outcome measures.Conclusion: LGG is modestly effective in decreasing the duration of RTIs. More RCTs investigating specific ...Continue Reading

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Citations

Jun 19, 2019·The Cochrane Database of Systematic Reviews·Anna M ScottChris B Del Mar
Jun 22, 2019·Microbial Biotechnology·Shari KiekensSarah Lebeer
May 15, 2019·Microorganisms·Franca RossiGiampaolo Colavita
Jun 25, 2020·Current Nutrition Reports·Savita BudhwarManali Chakraborty
Jul 28, 2019·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Nicola IrwinMarian Currie
Feb 12, 2019·Journal of Clinical Gastroenterology·Lucio Capurso
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Feb 2, 2021·Science China. Life Sciences·Jia LuoFeng Jin
Nov 25, 2020·BMJ Nutrition, Prevention & Health·Philip C Calder
May 25, 2021·Clinical Nutrition ESPEN·Iva HojsakKoen Joosten
Sep 12, 2021·Gastroenterology·Harry Cheuk-Hay LauJun Yu
Apr 5, 2019·Caries Research·Egija Zaura, Svante Twetman
Oct 21, 2021·Nutrition Research Reviews·Kamila Sabino BatistaJailane de Souza Aquino

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