Probiotics for the Prevention of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Controlled Trials.

Respiratory Care
Minmin SuJinsheng Jia

Abstract

Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. We conducted a meta-analysis of published randomized controlled trials to evaluate the efficacy and safety of probiotics for VAP prevention in patients who received mechanical ventilation. We searched a number of medical literature databases to identify randomized controlled trials that compared probiotics with controls for VAP prevention. The results were expressed as odds ratios (OR) or mean differences with accompanying 95% CIs. Study-level data were pooled by using a random-effects model. Data syntheses were accomplished by using statistical software. Fourteen studies that involved 1,975 subjects met our inclusion criteria. Probiotic administration was associated with a reduction in VAP incidence among all 13 studies included in the meta-analysis (OR 0.62, 95% CI 0.45-0.85; P = .003; I2 = 43%) but not among the 6 double-blinded studies (OR 0.72, 95% CI 0.44-1.19; P = .20; I2 = 55%). We found a shorter duration of antibiotic use for VAP (mean difference -1.44, 95% CI -2.88 to -0.01; P = .048, I2 = 30%) in the probiotics group than in the control group, and the finding comes from just 2 studies. No statistically significant d...Continue Reading

Citations

Jun 24, 2020·Frontiers in Public Health·David BaudEric Giannoni
Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Enrik John T AguilaEliezer James T Aguila
Mar 12, 2020·Intensive Care Medicine·Laurent PapazianCharles-Edouard Luyt
Oct 10, 2020·The British Journal of Nutrition·Gemma E WaltonKirsty A Hunter
Dec 23, 2020·The Annals of Pharmacotherapy·Ting JiXiangcheng Zhang
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elena Barengolts, Emily Daviau Smith
Feb 2, 2021·Journal of King Saud University. Science·Mysoon M Al-AnsariA J Ranjit Singh
Mar 2, 2021·Frontiers in Cellular and Infection Microbiology·Ashton HarperRichard Day
Mar 16, 2021·Frontiers in Immunology·Gislane Lelis Vilela de OliveiraCristina Ribeiro de Barros Cardoso
Apr 1, 2021·Archives of Medical Research·Shilia Jacob KurianMahadev Rao
Sep 15, 2020·The British Journal of Nutrition·Suresh Kumar Angurana, Arun Bansal
Aug 28, 2021·Microorganisms·Yuan-Pin HungWen-Chien Ko

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