Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer.

The Cochrane Database of Systematic Reviews
Dang WeiRob Jpm Scholten

Abstract

Treament-related diarrhoea is one of the most common and troublesome adverse effects related to chemotherapy or radiotherapy in people with cancer. Its reported incidence has been as high as 50% to 80%. Severe treatment-related diarrhoea can lead to fluid and electrolyte losses and nutritional deficiencies and could adversely affect quality of life (QoL). It is also associated with increased risk of infection in people with neutropenia due to anticancer therapy and often leads to treatment delays, dose reductions, or treatment discontinuation. Probiotics may be effective in preventing or treating chemotherapy- or radiotherapy-induced diarrhoea. To evaluate the clinical effectiveness and side effects of probiotics used alone or combined with other agents for prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 7), MEDLINE (1946 to July week 2, 2017), and Embase (1980 to 2017, week 30). We also searched prospective clinical trial registers and the reference lists of included studies. We included randomised controlled trials (RCTs) investigating the effects of probiotics for prevention or treatment of c...Continue Reading

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Citations

Apr 6, 2019·Cancer Medicine·Mansour SedighiEbrahim Kouhsari
Feb 23, 2020·Microorganisms·Benoit PilmisJean-Ralph Zahar
Jul 12, 2019·Frontiers in Cellular and Infection Microbiology·Pengjun ZhouYifei Wang
Jun 23, 2020·Integrative Cancer Therapies·Ratoe SurayaYoshihiro Nishimura
May 1, 2021·Nutrients·Louise PitsillidesChristos Kontovounisios

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