Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials.

Scientific Reports
Tícia KocsisMargit Solymár

Abstract

Probiotics have been reported to have a positive impact on the metabolic control of patients with type 2 diabetes. We aimed to systematically evaluate the effects of probiotics on cardiometabolic parameters in type 2 diabetes based on randomized controlled studies. MEDLINE, Embase, and CENTRAL databases were reviewed to search for randomized controlled trials that examined the effects of probiotic supplementation on cardiometabolic parameters in patients with type 2 diabetes. 32 trials provided results suitable to be included in the analysis. The effects of probiotics were calculated for the following parameters: BMI, total cholesterol levels, LDL, triglycerides, HDL, CRP, HbA1c levels, fasting plasma glucose, fasting insulin levels, systolic and diastolic blood pressure values. Data analysis showed a significant effect of probiotics on reducing total cholesterol, triglyceride levels, CRP, HbA1c, fasting plasma glucose, fasting insulin levels, and both systolic and diastolic blood pressure values. Supplementation with probiotics increased HDL levels however did not have a significant effect on BMI or LDL levels. Our data clearly suggest that probiotics could be a supplementary therapeutic approach in type 2 diabetes mellitus pa...Continue Reading

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Citations

Dec 22, 2020·Frontiers in Microbiology·Homa BazirehMohammad Ali Boroumand
Feb 14, 2021·Biomolecules·Maria Jose Carranza-NavalAngel Del Marco
Nov 5, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ludmilla Quaresma Teixeira CabralRicardo Fernandes
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Amir Reza MoravejolahkamiMarjan Mansourian
Oct 29, 2021·Indian Journal of Ophthalmology·Taraprasad DasRajiv Raman

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