Probiotics in cystic fibrosis patients: A double blind crossover placebo controlled study: Pilot study from the ESPGHAN Working Group on Pancreas/CF

Clinical Nutrition ESPEN
Stephanie Van BiervlietMichael Wilschanski

Abstract

A potential positive effect of probiotics in cystic fibrosis (CF) on fecal calprotectin (FCP), pulmonary exacerbations and weight has been described in small controlled trials. A double-blind multicenter cross-over study (2 × 4 m) was performed looking at abdominal pain, nutritional status, pulmonary function, pulmonary exacerbation, FCP and lactulose/mannitol gut permeability test. Patients kept a diary with daily scoring of abdominal pain, stool frequency and consistency as well as treatment changes. 31 CF patients entered the study of which 25 finished it. At start patients aged 9.3yrs (6.9-12.2), had a median BMI z-score of -0.5 (-1.5-0.08), height z-score of -0.4 (-1.1-0.05) and FEV1% of 100% (87.2-106.6). Median FCP at start was 61 μg/g (17-108) and gut permeability 0.079 (0.051-0.122). No significant changes were observed in the clinical parameters (BMI, FEV1%, abdominal pain, exacerbations). Despite being frequently abnormal (17/28 (61%) >50 mg/kg), FCP did not change significantly with probiotics. The proportion of patients with normal permeability was 8% during placebo and 32% during probiotic treatment (p = 0.031). FCP correlated to BMI z-score (p = 0.043) and gut permeability to abdominal pain (p = 0.015). The micro...Continue Reading

Citations

May 17, 2019·Expert Review of Respiratory Medicine·Carla ColomboGianfranco Alicandro
Nov 13, 2019·Pediatric Pulmonology·Kimberly AltmanKaren Maguiness
Jan 22, 2020·The Cochrane Database of Systematic Reviews·Michael J CoffeyChee Y Ooi
Aug 18, 2020·Journal of Immunology Research·Li ChunxiSu Jin
Mar 7, 2021·Metabolites·Aravind ThavamaniSenthilkumar Sankararaman
Jun 7, 2021·Lancet·Michal ShteinbergJane C Davies
Sep 13, 2020·Paediatric Respiratory Reviews·Michael J CoffeyChee Y Ooi
Aug 3, 2021·Journal of Bacteriology·Courtney E Price, George A O'Toole

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