Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Rikke Meineche SchmidtArne Høst

Abstract

Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization. In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. The intervention period was 6 months, and the parents answered web-based questionnaires on allergic symptoms and doctor's diagnosed allergic disease monthly. IgE was measured at baseline and follow-up. A total of 290 participants were randomized: 144 in the probiotic group and 146 in the placebo group. Mean age at intervention start was 10.1 months. At follow-up (mean age 16.1 months), the incidence of eczema was 4.2% in the probiotic group and 11.5% in the placebo group (P = 0.036). The incidence of asthma and conjunctivitis did not differ between groups, and no children presented with rhinitis. Sensitization was equal in the two groups at intervention start (7.5% and 9.5%, respectively), and two children in each group were ...Continue Reading

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Citations

Apr 30, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Jul 18, 2020·The Cochrane Database of Systematic Reviews·Berkeley N LimketkaiAkinlolu Adedayo Adepoju
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Aug 18, 2020·Journal of Immunology Research·Li ChunxiSu Jin
Nov 26, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sofia D'EliosDiego G Peroni
Jan 9, 2021·Frontiers in Pediatrics·Simona SestitoLicia Pensabene
Mar 19, 2021·Journal of Applied Microbiology·Yifan WuLanwei Zhang
Apr 4, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carol Stephanie C Tan-LimAimee Lou M Nano
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