Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Acta Pharmaceutica Sinica. B
Xueqin YangJunrong Du

Abstract

ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota-gut-brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood-brain barrier, decreased interleukin-6 and tumor necrosis factor-α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-κB (NF-κB) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings...Continue Reading

Citations

Sep 25, 2020·The FEBS Journal·Laura BonfiliAnna Maria Eleuteri
Dec 31, 2020·Nutrients·Ashwinipriyadarshini MegurAurelijus Burokas
Nov 10, 2020·Cytokine & Growth Factor Reviews·Angélica VincenziClaucia Fernanda Volken de Souza
Feb 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Shoaib TahirWei Zhang
Feb 16, 2021·Frontiers in Microbiology·Elisa C Ale, Ana G Binetti
Feb 23, 2021·Frontiers in Neuroscience·Nikolay SolovyevBernhard Michalke
Mar 13, 2021·Ageing Research Reviews·Xiao-Hang QianHui-Dong Tang
May 1, 2021·Microorganisms·Malena Dos Santos GuilhermeKristina Endres
May 6, 2021·Biomolecules·Vivek Kumar SharmaMohamed M Abdel-Daim
Jun 15, 2021·Frontiers in Aging Neuroscience·Shaochang WuZongxin Ling
Oct 2, 2021·Applied Microbiology and Biotechnology·Hong-Fang Ji, Liang Shen

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Methods Mentioned

BETA
transmission electron microscopy
Assay
enzyme-linked immunosorbent assay
ELISA
PCR
nuclear translocation

Software Mentioned

ProBiotic
ProBiotics
Image Pro Plus
QIIME
SPSS

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