Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice

Digestive Diseases and Sciences
Kathene Candace Johnson-HenryPhilip M Sherman

Abstract

Probiotics are characterized by their ability to interact with commensal microflora in the gastrointestinal tract to produce beneficial health effects. In vitro studies suggest that Lactobacillus species have the potential to suppress the growth of Helicobacter pylori. The goal of this study was to determine if pretreatment of mice with a commercial mixture of live probiotics (L. rhamnosus, strain R0011, and L. acidophilus, strain R0052) would suppress colonization of H. pylori, strain SS1. Thirty C57BL/6 female mice were divided into four groups: Group A was fed sterile water, group B received probiotics in sterile drinking water, group C was challenged orogastrically with H. pylori, and group D was pretreated with probiotics in drinking water prior to and following challenge with H. pylori. Rectal swabs, stomach homogenates, and luminal contents from ileum and colon were plated onto colistin nalidixic acid plates. Serial dilutions of stomach homogenates were plated onto H. pylori-sensitive agar plates and incubated under microaerophilic conditions. Tissue samples from the stomach were analyzed histologically to determine the degree of H. pylori colonization, mucosal inflammation, and epithelial cell apoptosis. Probiotics in d...Continue Reading

Citations

Mar 17, 2005·Current Treatment Options in Gastroenterology·Mae F Go
Apr 16, 2005·Current Opinion in Biotechnology·Maija SaxelinWillem M de Vos
Mar 21, 2012·The Journal of Infectious Diseases·David M RodriguesMélanie G Gareau
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Cynthia ZamanShigeru Kamiya
Apr 27, 2010·Applied and Environmental Microbiology·Simone GuglielmettiDiego Mora
Apr 16, 2009·Clinical Microbiology Reviews·Freddy HaesebrouckRichard Ducatelle
Mar 29, 2013·Clinical and Vaccine Immunology : CVI·Jessica McClemensWaliul I Khan
Apr 21, 2012·International Journal of Inflammation·Sarika AmdekarPoonam Sharma
Jan 27, 2010·World Journal of Gastroenterology : WJG·Yi CuiFang-Gen Lu
Jun 2, 2012·World Journal of Gastroenterology : WJG·Chompoonut SunanliganonNaruemon Klaikeaw
Nov 28, 2012·World Journal of Gastroenterology : WJG·Yi-Qi DuZhao-Shen Li
Dec 24, 2013·World Journal of Gastroenterology : WJG·Ko Eun LeeYoung Do Jung
Oct 4, 2014·The Journal of Microbiology·Jin-Eung KimDo-Young Yum
Jul 16, 2010·Digestive Diseases and Sciences·Basileios G SpyropoulosChristos N Stoidis
Jun 13, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ami PatelJ B Prajapati
Mar 2, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Maha A KhalilMohamed Z Hussein
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·M GottelandS Cruchet
Feb 26, 2009·Letters in Applied Microbiology·K A RyanP W O'Toole
Jan 28, 2015·Journal of Digestive Diseases·Christian SchulzPeter Malfertheiner
Oct 7, 2015·Frontiers in Microbiology·Silvia BalzarettiSimone Guglielmetti
Oct 30, 2013·Journal of Medical Microbiology·Cynthia ZamanShigeru Kamiya
Mar 24, 2015·Nutrition Research·Jed W FaheyAlison J Wallace
Feb 11, 2015·Experimental and Therapeutic Medicine·Zhifa LvNonghua Lv
Jun 16, 2016·Frontiers in Microbiology·Manuel J Saint-CyrNabila Haddad
Aug 10, 2016·Frontiers in Microbiology·Mydhily R B NairSantanu Chattopadhyay
Sep 30, 2016·Microorganisms·María José Salas-JaraApolinaria García
Jan 1, 2013·Pathogens·Janice J Kim, Waliul I Khan

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