Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression

Behavioural Brain Research
Sandra Tillmann, Gregers Wegener

Abstract

Several studies have reported beneficial effects of probiotics on behavior and stress in humans and animals. The multi-strain probiotic product Ecologic® Barrier has shown antidepressant-like effects in rats when given in combination with high-fat diet. To circumvent the need for high-fat diet for future clinical use, the present study aimed to potentiate the behavioral effects of Ecologic® Barrier by developing a customized product that includes four additional bacterial species known to be associated with depression. Flinders Sensitive Line (FSL) rats, an animal model of depression, were randomized to receive vehicle, Ecologic® Barrier, or the customized product Ecologic® Barrier + 4. The control strain, Flinders Resistant Line rats, received vehicle to ascertain the depressive-like phenotype of FSL rats. Behavior was tested in the Elevated Plus Maze, Y-Maze, Novel Object Recognition Test, Open Field, and Forced Swim Test; HPA-axis reactivity was assessed by the Dexamethasone Suppression Test. Our results indicate that both probiotic products reduced open arm exploration in the Elevated Plus Maze, suggesting a reduction in risk-taking behavior. There were no intervention effects on cognition, locomotion, or depressive-like be...Continue Reading

Citations

Oct 2, 2019·International Journal of Molecular Sciences·Yuanzhen HaoYun Gao
Oct 3, 2020·Frontiers in Behavioral Neuroscience·Mimi La-VuAvishek Adhikari
Sep 17, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anders AbildgaardGregers Wegener
Dec 3, 2020·Frontiers in Psychiatry·Alison Accarie, Tim Vanuytsel
Apr 27, 2021·Frontiers in Behavioral Neuroscience·Haiyan ZengHaiyun Xu
Jun 25, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Subramanyam PolopalliPhani Kumar Kola

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