Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical Study.

Journal of Cardiovascular Translational Research
Jalal MoludiSevda Saleh Ghadimi

Abstract

Adverse cardiac remodeling after myocardial infarction (MI) can lead to the syndrome of heart failure (HF). Recently, changes in gut microbiota composition (dysbiosis) have appeared as a novel candidate that may be linked to the development of CR and HF. The aim of this trial was to evaluate the effects of probiotics administration on attenuating CR in patients with MI. A single-center double-blind placebo-controlled stratified randomized clinical study was conducted in 44 subjects with MI who underwent percutaneous coronary intervention (PCI). Patients were randomly assigned to take, with lunch, either a probiotic capsule containing 1.6 × 109 colony-forming unit (CFU) of bacteria (treatment group) or capsules contained inulin (control group) over 3 months. CR biomarkers (including serum procollagen III, transforming growth factor beta (TGF-β), trimethylamine N-oxide (TMAO), and matrix metallopeptidase 9 (MMP-9)) were assessed. Echocardiography results were measured at baseline and after the intervention. Significant decreases were seen in serum TGF-β concentrations (- 8.0 ± 2.1 vs. - 4.01 ± 1.8 pg/mL, p = 0.001) and TMAO levels (- 17.43 ± 10.20 vs. - 4.54 ± 8.7 mmol/L, p = 0.043), and there were no differences were seen in MMP...Continue Reading

References

Jun 11, 2003·American Journal of Epidemiology·Jens P HellermannVéronique L Roger
Jul 15, 2003·Internal Medicine·Hiroyuki TakanoIssei Komuro
Aug 24, 2006·Public Health Nutrition·Maria HagströmerMichael Sjöström
Dec 21, 2006·Folia Microbiologica·I Trebichavský, I Splíchal
Jun 5, 2007·Current Cardiology Reports·Markus Flesch, Erland Erdmann
Jul 16, 2008·Inflammatory Bowel Diseases·S C NgS C Knight
Mar 31, 2009·Journal of Cardiac Failure·José Paulo AraújoPaulo Bettencourt
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Bruno EbelPatrick Gervais
Jan 15, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sin Ji LeeHojun Kim
Oct 12, 2014·Current Cardiology Reports·Matteo SerinoRemy Burcelin
Feb 27, 2015·World Journal of Cardiology·Michael A GarzaJohn Q Zhang
Jun 2, 2015·Frontiers in Immunology·Karin de Punder, Leo Pruimboom
Aug 25, 2015·Diabetes & Metabolism Journal·Mélanie Le BarzAndré Marette
Feb 7, 2016·The Lancet. Psychiatry·Daniel VigoRifat Atun
Feb 18, 2016·Current Heart Failure Reports·Takeshi KitaiW H Wilson Tang
Apr 15, 2016·International Journal of Medical Sciences·Chao-Hung LaiChih-Yang Huang
Oct 1, 2016·Tropical Life Sciences Research·Lye Huey ShiOoi Shao Yin
Mar 21, 2017·Current Treatment Options in Cardiovascular Medicine·Allyson Zabell, W H Wilson Tang
Aug 9, 2017·Cardiac Failure Review·Gianluigi Savarese, Lars H Lund
Nov 15, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh Zununi VahedGraciela Pavon-Djavid
Apr 27, 2018·JAAPA : Official Journal of the American Academy of Physician Assistants·Georgia TannerTanya Gregory
Aug 3, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zehua LiMinsheng Chen
Sep 7, 2019·Journal of Cellular Physiology·Akash K GeorgeSuresh C Tyagi

❮ Previous
Next ❯

Citations

Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Wei ZhaoJianhui Rong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Related Papers

The British Journal of Surgery
G C O'Sullivan
The Medical Letter on Drugs and Therapeutics
International Journal of Food Microbiology
F Guarner, G J Schaafsma
The Veterinary Record
G Meller
© 2021 Meta ULC. All rights reserved