Problem areas in the understanding of informed consent for research: study of middle-aged and older patients with psychotic disorders

Psychopharmacology
L B Dunn, Dilip V Jeste

Abstract

Optimizing the abilities of individuals with psychiatric disorders to provide meaningful informed consent for research has become a heightened concern for psychiatric researchers. We examined a post-consent test of comprehension given to older patients with psychotic disorders to identify problem areas in the understanding of informed consent for research. One hundred and two middle-aged and older outpatients with schizophrenia or related psychotic disorders and twenty normal comparison subjects were administered a 20-item questionnaire to assess their comprehension of consent for a low-risk research protocol after receiving either a routine (paper-based) or an enhanced (computerized, structured slide show incorporating greater review) consent procedure. Data on individual questions were analyzed. Patients had more difficulty than normal comparison subjects on open-ended questions, including those asking about study procedures, time involved, and potential risks and benefits. Among patients, the enhanced procedure was associated with better performance on questions about potential risks and time required than the routine procedure. Problem areas in the understanding of informed consent, such as study procedures and potential ri...Continue Reading

Citations

Jan 1, 2011·AJOB Primary Research·James DuboisWhitney B Hadley
Sep 24, 2005·Schizophrenia Bulletin·Laura B DunnMonique Keehan
Apr 28, 2006·Current Opinion in Psychiatry·Laura B Dunn, Laura Weiss Roberts
Nov 1, 2007·Journal of Medical Ethics·K K Anderson, S D Mukherjee
Feb 3, 2007·AIDS Care·D A MurphyUNKNOWN Adolescent Trials Network for HIV/AIDS Interventions
Mar 19, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Daniel C Marson
Aug 3, 2006·Behavioral Sciences & the Law·Laura B Dunn
May 18, 2006·Behavioral Sciences & the Law·David ShoreChristine Moretto Wishnoff
Jan 25, 2007·International Journal of Geriatric Psychiatry·Patricia A Areán, George Alexopoulos
Jun 15, 2018·BMC Public Health·Nucharapon LiangruenromZeljko Pedisic
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Adib Essali, Ghassan Ali
Sep 26, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Peter LeppingJim Turner
Apr 6, 2006·The Annals of Pharmacotherapy·Peter F J Schulte

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