PMID: 8599402Apr 1, 1996Paper

Problem of diagnosis in postmortem brain studies of schizophrenia

The American Journal of Psychiatry
C HillD Copolov

Abstract

The purpose of this study was to determine 1) the reliability of diagnoses of schizophrenia at coronal autopsy and 2) the degree to which the use of different diagnostic instruments for schizophrenia would affect postmortem brain research. Eighty-three subjects, recorded at coronal autopsy as having had schizophrenia, were referred for neurochemistry studies. The diagnoses reported to the state coroner's office were reevaluated by a review of psychiatric case histories by clinicians using semistructured assessment and diagnostic criteria. The application of DSM-III-R, Research Diagnostic Criteria (RDC), ICD-10, Schneiderian, and Feighner criteria to the diagnosis of the 83 subjects revealed that 63.9%, 48.2%, 48,2%, 43.4%, and 42.2%, respectively, met the criteria for schizophrenia. Highest concordance was between the RDC and ICD-10 systems, while lowest concordance was between the RDC and Schneider systems. These data suggest that unless carefully reviewed, diagnosis may be a major confounding factor in postmortem studies of brain tissue from subjects with schizophrenia.

Citations

Sep 18, 1996·Schizophrenia Research·B Dean, W Hayes
Feb 9, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clarissa TrzesniakJosé Alexandre S Crippa
Mar 10, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brian Dean, Elizabeth Scarr
Nov 11, 2008·Annals of the New York Academy of Sciences·Elin Lehrmann, William J Freed
Dec 21, 2004·Biological Psychiatry·Amy Deep-SoboslayJoel E Kleinman
Oct 12, 2004·Schizophrenia Research·Carmit NadriGalila Agam
Mar 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·David G WheelerClive G Harper
Apr 12, 2005·Biological Psychiatry·Alison DigneyBrian Dean
Aug 5, 2015·Translational Psychiatry·M UdawelaI P Everall
Aug 12, 2008·Schizophrenia Research·Brian DeanElizabeth Scarr
Feb 18, 2012·The International Journal of Neuropsychopharmacology·Andrew Stuart GibbonsBrian Dean
Aug 17, 2016·Translational Psychiatry·P LiuH Zhang
Nov 9, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·K HamazakiT Yoshikawa
May 28, 2015·The Australian and New Zealand Journal of Psychiatry·Brian DeanRobert E McCullumsmith
Feb 16, 2006·The Australian and New Zealand Journal of Psychiatry·Brian DeanElizabeth Scarr
Jul 25, 2009·The Australian and New Zealand Journal of Psychiatry·Dennis VelakoulisCatriona McLean
Feb 6, 2008·The Australian and New Zealand Journal of Psychiatry·Nina SundqvistClive Harper
Jan 16, 2010·The Australian and New Zealand Journal of Psychiatry·Cynthia Shannon WeickertClive Harper
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Brian DeanElizabeth A Thomas
Nov 26, 2010·The Australian and New Zealand Journal of Psychiatry·Madhara UdawelaBrian Dean
Feb 28, 2003·Alcoholism, Clinical and Experimental Research·Clive HarperRoger Butterworth
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Iris DepazPeter A Wilce
Apr 17, 2015·The Cochrane Database of Systematic Reviews·Karla Soares-WeiserClive E Adams
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria S DaltonKaterina Zavitsanou
Jul 30, 2011·Journal of Neurogenetics·Erika PedrosaHerbert M Lachman
Oct 28, 2018·Electrophoresis·Georgia M ParkinBrian Dean

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BMJ : British Medical Journal
Moayed Alawami, Hassan J Alduhailib
Archives of Otolaryngology--head & Neck Surgery
E P Liebman
© 2021 Meta ULC. All rights reserved