PMID: 8582152Oct 1, 1995Paper

Problems and suggested solutions in creating an archive of clinical trials data to permit later meta-analysis: an example of methotrexate trials in rheumatoid arthritis

Controlled Clinical Trials
M C ChernoffD T Felson

Abstract

Because data archives contain patient-based rather than study-based data, they can address meta-analytic questions on uncommon outcomes and on predefined patient subsets, questions that are difficult to address using the traditional meta-analytic approach based on grouped data. We report the tasks involved in establishing the first data archive of rheumatoid arthritis trials. In general, problems stem from the heterogeneity of trials in the archive and we suggest some solutions. In the initial phases, difficulties include recruitment and incomplete participation of trial investigators, whereas later on, other issues arise, such as quality control, coping with different dataset designs, and incomplete documentation. Other issues include heterogeneous measures, missing variables, and comparing data across different visit intervals and trial lengths. Suggested solutions include requesting trial data in predefined archive-wide structures and asking for all possible documentation for each dataset. Data cleaning is necessary, as is rescaling of variables or developing unit-free outcomes, and estimating data for missing variables. Archive design should allow for referencing a patient's data among various datasets. Although one goal is...Continue Reading

References

Aug 1, 1992·Journal of Clinical Epidemiology·D T Felson
Sep 1, 1991·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·R M Renwick
Jun 1, 1990·Ryūmachi. [Rheumatism]·T ShinozawaM Homma
Jan 1, 1990·Arthritis and Rheumatism·J F FriesH B Hubert
Dec 1, 1989·Controlled Clinical Trials·B A Blumenstein
Mar 1, 1988·Controlled Clinical Trials·B S HawkinsR L Mowery
Mar 28, 1985·The New England Journal of Medicine·M E WeinblattD E Trentham
Apr 1, 1994·Arthritis and Rheumatism·H A Fuchs, T Pincus
Aug 16, 1985·Science·C Norman
May 1, 1994·Environmental Monitoring and Assessment·J C MorlotS Lurding

❮ Previous
Next ❯

Citations

Oct 12, 2000·Journal of Women's Health & Gender-based Medicine·C M MazureM Killien
Jun 16, 2004·Cephalalgia : an International Journal of Headache·C BarrowsUNKNOWN SNAP Study Group
Jan 1, 1997·Fundamental & Clinical Pharmacology·P NonyJ P Boissel
Nov 13, 2003·Arthritis and Rheumatism·Jennifer J AndersonDavid T Felson
Mar 7, 2007·Statistical Methods in Medical Research·Jennifer J Anderson
Mar 24, 1998·International Journal of Technology Assessment in Health Care·D CoyleM F Drummond
Sep 14, 2012·Toxicologic Pathology·Dianne CreasyKatharine Whitney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.